53 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.
47 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review examines the pathogenesis of premature hair graying and potential treatment avenues, but reports no new experimental outcomes, highlighting ongoing research challenges and hopes for drug development.
46 citations
,
April 2014 in “PLOS ONE” This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.
46 citations
,
November 1997 in “Journal of Neural Transmission” Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.
43 citations
,
February 2008 in “Journal of cutaneous pathology” This study revealed that during fetal development, MITF and Mart-1 expressing melanocytes progress from the dermis to the epidermis and hair follicles, with MITF possibly marking follicular stem cells.
41 citations
,
April 2019 in “PLOS genetics” This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.
40 citations
,
January 2016 in “Elsevier eBooks” This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.
33 citations
,
December 2015 in “International Journal of Molecular Sciences” This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.
27 citations
,
August 2006 in “Laboratory Investigation” In this study, the combination of SCF and ET-1 was found to significantly enhance skin pigmentation and melanin content in human skin xenografts on SCID mice compared to either treatment alone.
26 citations
,
September 2012 in “Cell Reports” In this study, knockout of B-raf and C-raf genes in mice showed they are not needed for early melanocyte development, but are crucial for maintaining melanocyte stem cells, as evidenced by hair graying due to stem cell depletion.
20 citations
,
January 2013 in “Cell & Bioscience” This review discusses recent findings on the epigenetic regulation of adult stem cells and cancer stem cells, highlighting shared and distinct features, and reports no new clinical results.
18 citations
,
July 2018 in “Journal of Cosmetic Dermatology” This study found that microneedling combined with calcipotriol plus betamethasone was more effective in treating vitiligo than microneedling with tacrolimus, particularly in difficult-to-treat areas.
15 citations
,
June 2021 in “International Journal of Molecular Sciences” This study demonstrated that novel curcumin analogs CMC2.24, CMC2.23, and CMC2.5 were more effective and less toxic than parent curcumin in inhibiting melanin production in normally pigmented human melanocytes, suggesting potential for skin depigmentation therapies.
15 citations
,
December 2016 in “Obstetrics & Gynecology” This review discusses the effects of pregnancy on melanocytic nevi and reports no new clinical results; it suggests that changing nevi during pregnancy should be evaluated similarly to those in nonpregnant patients.
13 citations
,
May 2022 in “Cell discovery” This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.
13 citations
,
March 2020 in “Frontiers in cell and developmental biology” This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.
13 citations
,
July 2012 in “Pigment Cell & Melanoma Research” In this study, researchers identified a new dominant mutation in Hairless mice, called Pied, resulting from a deletion in the Adam10 gene, which causes freckle-like skin pigmentation by inhibiting melanocyte expansion.
12 citations
,
September 2020 in “Nanomaterials” This study found that centrifugally spun scaffolds with higher concentrations of platelet-derived bioactive molecules enhanced melanocyte metabolic activity and proliferation, suggesting potential for improving vitiligo treatment.
10 citations
,
May 2023 in “iScience” In this study, researchers found that Sox9 is critical for determining whether Nestin+ stem cells in adult mouse skin develop into melanocytes or glial cells, offering insights into possible paths for melanoma research.
10 citations
,
May 2012 in “PloS one” This study found that non-pigmented hair follicles have significantly lower expression of nucleotide excision repair genes, which may be associated with reduced melanin production capacity in these follicles.
9 citations
,
January 2017 in “Elsevier eBooks” This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.
9 citations
,
May 2012 in “PLOS ONE” This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.
7 citations
,
February 2019 in “International Journal of Dermatology” This review discusses factors influencing hair pigmentation and the etiology of canities, noting the lack of clarity in underlying mechanisms and calling for further research on treatment options.
7 citations
,
November 2011 in “Skin Research and Technology” The authors observed that the patterned melanoderma on the hairless scalp of fair-skinned Caucasian men with androgenic alopecia resembled similar patterns seen on facial skin.
7 citations
,
October 2011 in “BMC Cancer” This study found no evidence that HDGF expression transforms melanocytes into tumors in a mouse model, although it may play a role in cell differentiation and tumor progression.
6 citations
,
September 2022 in “Frontiers in pharmacology” In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.
6 citations
,
November 2013 in “International Journal of Radiation Biology” In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.
6 citations
,
January 2009 in “Elsevier eBooks” This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.
6 citations
,
January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
4 citations
,
March 2024 in “Journal of Investigative Dermatology” SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.