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GlossaryMelanogenesis (Melanin Synthesis)

process of producing melanin in skin and hair cells

Melanogenesis is the process by which the skin and hair produce melanin, the pigment responsible for their color. This process occurs in specialized cells called melanocytes and involves a series of biochemical reactions, primarily catalyzed by the enzyme tyrosinase. Melanogenesis is influenced by genetic factors, UV exposure, and hormonal changes, and plays a crucial role in protecting the skin from UV radiation.

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Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations, August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation

56 citations, November 2010 in “Pigment Cell & Melanoma Research”

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

research Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine

15 citations, December 2016 in “Advanced Pharmaceutical Bulletin”

The new cream with N-acetyl glucosamine didn't change skin color after 8 weeks.

Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

210 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

research Epimedium Brevicornum Maxim Extract Enhances Melanin Biosynthesis and Melanosome Biogenesis/Transfer

6 citations, September 2022 in “Frontiers in pharmacology”

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

research Melanogenesis-Promoting Effect of Cirsium Japonicum Flower Extract In Vitro and Ex Vivo

4 citations, October 2021 in “International Journal of Cosmetic Science”

Cirsium japonicum flower extract increases melanin production and could help treat depigmentation conditions.

research Expression and Tissue Distribution Analysis of Angiotensin II in Sheep Skins Associated with White and Black Coat Colors

3 citations, March 2019 in “Acta histochemica”

Angiotensin II is found at higher levels in black sheep skin and may influence coat color.

research Exploring the Potential Effect and Mechanisms of Protocatechuic Acid on Human Hair Follicle Melanocytes

3 citations, May 2020 in “Acta pharmaceutica”

Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.

research The Nutritional Biochemistry of Wool and Hair Follicles

14 citations, April 2000 in “Animal Science/Animal science”

Nutrients like vitamins, copper, zinc, and amino acids are crucial for healthy hair and wool growth.

research Platelet-Rich Plasma in Melasma: A Systematic Review

5 citations, October 2021 in “Dermatologic Surgery”

Platelet-rich plasma (PRP) can significantly improve melasma, a skin pigmentation disorder, but may not add benefits when used with certain other treatments.

research Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage

210 citations, May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.

research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations, January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color is determined by melanin produced and transferred in hair follicles.

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations, June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair stops producing melanin as it transitions from the growth phase to the resting phase.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Intrinsic and Extrinsic Factors Associated with Hair Graying and Therapeutic Potential of Plant Extracts and Phytochemicals

August 2024 in “Applied Sciences”

Plant extracts may help prevent or reverse hair graying.

research Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics

January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Rhamnose may help hair growth and pigmentation, making it a potential treatment for hair loss.

research Platelet-Rich Plasma in Dermatology: Cellular and Molecular Mechanisms of Action

3 citations, December 2023 in “Biomedicines”

PRP therapy helps skin heal and improve by promoting cell growth and repair.

research The Molecular Mechanism of PCE-DP, a Novel Brightening Active Ingredient

September 2019 in “Journal of Investigative Dermatology”

PCE-DP brightens skin and promotes hair growth by enhancing cell growth and reducing melanin uptake.

Immunohistopathological Analysis of Frizzled-4-Positive Immature Melanocytes from Hair Follicles of Patients with Rhododenol-Induced Leukoderma

research Immunohistopathological Analysis of Frizzled-4-Positive Immature Melanocytes from Hair Follicles of Patients with Rhododenol-Induced Leukoderma

8 citations, August 2015 in “Journal of dermatological science”

Rhododendrol in skin-whitening products can cause skin depigmentation and immune reactions.

research Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

35 citations, January 2011 in “Journal of Biological Chemistry”

sPLA2-X is crucial for normal hair growth and follicle health.

research Photobiomodulation in Dermatology: Harnessing Light from Visible to Near Infrared

9 citations, January 2018 in “Medical research archives”

Low-intensity light therapy is effective for skin healing, reducing inflammation, and treating various skin conditions.

research An Update on Drug-Induced Pigmentation

20 citations, October 2018 in “American Journal of Clinical Dermatology”

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.

research The Potential Impact of Melanosomal pH and Metabolism on Melanoma

3 citations, November 2022 in “Frontiers in Oncology”

Melanin may help melanoma cells grow by aiding their metabolism.

research Platelet-Rich Plasma Is a Promising Therapy for Melasma

11 citations, May 2021 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma therapy could be an effective treatment for melasma with minimal side effects.

research The Antimycotic Agent Clotrimazole Inhibits Melanogenesis by Accelerating ERK and PI3K/Akt-Mediated Tyrosinase Degradation

15 citations, March 2015 in “Experimental Dermatology”

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

research Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth

109 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.