34 citations
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July 2006 in “The Journal of Comparative Neurology” This study found that overexpression of neurotrophin 4 in mouse skin increased hair follicle and Meissner corpuscle innervation without altering sensory neuron numbers, differing from brain-derived neurotrophic factor by not affecting Merkel cell numbers.
13 citations
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August 2023 in “Developmental Cell” In this study, researchers observed that mechanosensory neurons initially develop similar morphologies across different skin regions but diverge post-natally, adapting to the type of skin they innervate, with bone morphogenetic protein signaling crucial for forming Meissner corpuscles in glabrous skin.
5 citations
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March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.
February 2019 in “American International Journal of Humanities Arts and Social Sciences” This histological study of Millivora Capenesis skin describes the composition of the dermis, featuring distinct papillary and reticular layers with associated structures like hair follicles, glands, and corpuscles.
January 1981 in “Purdue e-Pubs (Purdue University)” This study observed that the pig integument is similar to human skin in both light and electron microscopy, with minimal postnatal developmental differences noted.
6 citations
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September 2021 in “Experimental Brain Research” In this study, researchers found that the glabrous skin of the rat forelimb contains sparse Meissner corpuscles and Merkel complexes, with more slowly adapting afferents in the palm and rapidly adapting afferents in the digit extremity.
110 citations
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January 1983 in “Brain Research Reviews” This study found that the vermilion border and mucosa of the monkey lip have a dense sensory innervation, which correlates with their known tactile sensitivity.
January 2024 in “Archives of pharmacy practice” This study reviews the embryological origins, anatomical and histological structure, and key functions of the skin, emphasizing its protective, sensory, and regulatory roles, as well as the social and psychological impacts of post-lesion changes.
123 citations
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November 2003 in “Neuroscience Letters” In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.
127 citations
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December 2007 in “Journal of Investigative Dermatology” This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.
This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.
March 2015 in “Plastic and reconstructive surgery” This chapter reviews the skin's structure and its clinical relevance, highlighting connective tissue diseases and the potential for novel treatments like protein, cell, or stem cell transfer, but reports no new findings.
May 1995 in “Journal of Investigative Dermatology” Researchers developed a new way to measure gene activity in single hair follicles and found that a specific gene's activity changes with different amounts and times of treatment.
January 2025 in “International Journal For Multidisciplinary Research” In this study, the researchers developed and evaluated eco-friendly poly-herbal soap strips using plant extracts from Lantana camara, Moringa Oleifera, and Corn silk, finding that the strips exhibited superior physicochemical properties and significant anti-fungal activity compared to conventional anti-fungal soaps.
March 2024 in “International Research Journal Of Modernization In Engineering Technology And Science” This review highlights the beneficial effects of certain herbal drugs in treating skin diseases, such as their healing, antifungal, antiviral, antibacterial, anti-inflammatory, and antitumor-promoting activities, emphasizing recent technical advancements in the field over the past 17 years.
286 citations
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April 2009 in “The journal of neuroscience/The Journal of neuroscience” This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.
1 citations
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February 2020 in “Journal of Cosmetic Dermatology” In this study, the researchers found that scalp sensitivity decreased by less than 39% in patients who underwent hair transplant surgery compared to healthy controls.
277 citations
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July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
142 citations
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September 2020 in “Journal of neurophysiology” This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.
46 citations
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July 2007 in “Journal of comparative neurology” This study found that Florida manatees have unique types of specialized nerve endings in their vibrissae, which assist in their sensory and manipulative functions in aquatic environments.
46 citations
,
May 1986 in “Seminars in Reproductive Medicine” Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
40 citations
,
January 2016 in “Elsevier eBooks” This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.
27 citations
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October 1999 in “Experimental and Molecular Pathology” This article reviews potential animal models for studying androgenetic alopecia and reports no new experimental results; the authors highlight the need for further development of rodent models.
18 citations
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April 1986 in “International Journal of Cosmetic Science” In this study with stumptailed macaques, topical minoxidil successfully induced hair regrowth on bald scalps and prevented baldness on non-bald scalps, with no observed side effects over nearly three years.
8 citations
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January 1996 in “Springer eBooks” This article discusses the minimal research on hair growth physiology and highlights Dr. Masumi Inaba's contributions to understanding androgenetic alopecia, but reports no new experimental results.
8 citations
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October 1988 in “Clinics in dermatology” This paper discusses the lack of a genetic model for androchronogenic alopecia in rodents, noting the stumptailed macaque as a better current model due to its similarities to human male-pattern baldness; it reports no new results.
6 citations
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January 2009 in “Elsevier eBooks” This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.
4 citations
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study estimates that approximately 230,000 tactile afferent fibers innervate the human body's skin, with varying densities across different regions correlating with spatial acuity and hair follicle density.
2 citations
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January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study applied a new RGB trichrome stain to human skin samples, revealing distinct structural staining in normal tissues and potential proteoglycan-rich zones in hair follicles.