48 citations
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July 1988 in “PubMed” In this study, researchers observed that rhino mice exhibit significant ductal hyperkeratinization in the meibomian gland, which may represent the first naturally occurring disorder of this gland in mice.
16 citations
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September 2019 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that the retinol dehydrogenases SDR16C5 and SDR16C6 in mice play a crucial role in skin retinol dehydrogenase activity, affecting hair growth and gland functions without impacting survival.
15 citations
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June 2021 in “Medicina” This study found that combined intense pulsed light and low-level light therapy significantly improved ocular surface outcomes and quality of life for patients with meibomian gland dysfunction and dry eye disease.
13 citations
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January 2016 in “Journal of Ophthalmology” This study found that using the novel eyelid shampoo ESL improved eyelid hygiene, reduced dry eye symptoms in meibomian gland dysfunction patients, and increased eyelash length over 8 weeks.
6 citations
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October 2011 in “ISRN Ophthalmology” This study found that increased serum testosterone and dehydroepiandrosterone sulphate levels may serve as diagnostic markers for seborrheic meibomian gland dysfunction in both genders.
5 citations
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September 2009 in “Acta Ophthalmologica” This study found that the Meibomian gland shares structural and cytokeratin composition similarities with hair follicles, and plays a role in hyper-keratinisation observed in obstructive Meibomian gland dysfunction.
2 citations
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September 2010 in “Acta Ophthalmologica” The study concluded that all parts of the normal human Meibomian gland ductal system show signs of early keratinisation, supporting the idea that these glands are akin to "hair follicles without a hair shaft.
1 citations
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September 2025 in “Eye” This pharmacovigilance study found that certain systemic medications, including finasteride, bortezomib, and dupilumab, were disproportionately reported in association with eyelid disorders like blepharitis, meibomian gland dysfunction, and chalazia, suggesting these drugs may contribute to these conditions though benefits might still outweigh the risks.
1 citations
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September 2019 in “Journal of surgery and medicine” This study found that women with polycystic ovary syndrome had worse meibomian gland morphology and ocular surface conditions compared to healthy controls, as observed through non-contact meibography.
January 2025 in “Mansoura Medical Journal” In this animal study, researchers observed that both aging and lower androgen levels in male albino rats led to significant structural changes in meibomian glands, including reduced acinar cell size, diminished meibum secretion, and increased collagen deposition.
January 2025 in “Clinical and Experimental Optometry” This study found that men with androgenetic alopecia had significantly higher rates of dry eye symptoms and meibomian gland dysfunction compared to healthy controls, suggesting a potential link between the condition and these ocular issues.
January 2025 in “Turkiye Klinikleri Journal of Ophthalmology” This study found no significant differences in dry eye disease parameters between female patients with androgenetic alopecia and healthy controls, although meibum quality was better in the alopecia group, suggesting complex hormonal interplay affecting ocular health.
This study found that men with benign prostate hyperplasia showed increased meibomian gland dysfunction and tear film instability compared to age-matched controls, and were also more likely to have androgenic alopecia.
March 2024 in “International journal of molecular sciences” This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, primary cilia were found to contribute to meibomian gland enlargement and lipid production, though they are not necessary for normal gland development.
July 2021 in “International Ophthalmology” Female hair loss patients more likely to have dry eye and gland issues.
3 citations
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October 2021 in “Research Square (Research Square)” This study used in vivo confocal microscopy and a ResNet34 deep learning model to classify meibomian gland images with an AUROC greater than 0.95, indicating its potential for automatic diagnosis and screening of meibomian gland dysfunction.
January 2025 in “Journal of Imaging Informatics in Medicine” 19 citations
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October 2022 in “The Ocular Surface”
16 citations
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April 1978 in “Genetics Research” This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.
April 2018 in “Journal of Investigative Dermatology” Mutations in Far2 mice cause hair loss due to sebaceous gland issues.
January 2016 in “Institutional Repositories DataBase (IRDB)” This study examined the expression of fatty acid transporters and binding proteins in mouse sebaceous glands and found that CD36 did not affect the localization of other related molecules.
32 citations
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January 2016 in “Development” This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
11 citations
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January 2013 in “Ocular Surface” This review summarizes the ophthalmic complications of common periocular aesthetic treatments but reports no new clinical findings, emphasizing the importance of recognizing potential side effects.
4 citations
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January 2021 in “Dermatology Review” This review discusses the role of Demodex mites in ocular demodecosis and various eye ailments, highlighting diagnostic methods but noting a lack of standardized treatments, with no new clinical results reported.
3 citations
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October 2019 in “CRC Press eBooks” This review discusses isotretinoin's effectiveness against severe acne vulgaris and its associated side effects, including teratogenicity and hair loss, but it reports no new experimental results.
1 citations
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June 2023 in “Cureus” In a retrospective study, researchers found that topical spironolactone improved tear film quality and reduced inflammation related to meibomian gland dysfunction and evaporative dry eye in patients, demonstrating good tolerability and suggesting it as a potential therapy for managing the condition.
June 2022 in “Indian journal of clinical and experimental opthalmology” This case report details the ocular complications of Hutchinson-Gilford Progeria syndrome in a 20-year-old Bangladeshi patient, highlighting symptoms like dry eyes, Meibomian gland dysfunction, and cataracts.
December 2011 in “Ophthalmology” This article discusses the potential association between Demodex and blepharitis but reports no new findings, as the authors evaluated systemic associations without data on Demodex infestation.
June 2023 in “Journal of biological chemistry/The Journal of biological chemistry” This study on Sdr16c5/Sdr16c6-null mice found that inactivating these genes significantly increased Meibomian gland secretions and altered lipid profiles but had a subtle impact on sebogenesis, suggesting the genes control a bifurcation point in meibogenesis pathways.