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MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

There is no standardized treatment for hidradenitis suppurativa, and individualized plans are needed.

Budesonide is not effective for maintaining remission in Crohn's disease beyond three months.

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.

Different treatments for Hidradenitis suppurativa range from antibiotics and hormonal therapies to surgery, depending on severity.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

No single treatment is clearly effective for central serous chorioretinopathy.

Mycophenolate mofetil may improve lupus nephritis remission more than cyclophosphamide but with uncertain safety.

Bimatoprost is effective for growing longer, thicker, and darker eyelashes.

Janus kinase inhibitors show promise in treating alopecia areata but need better topical formulations.

9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.

Minoxidil 2% and 5% are common treatments for female pattern hair loss, with other options including anti-androgens, oral contraceptives, and hair transplantation.

Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.

Photobiomodulation therapy helps manage cancer treatment side effects but needs more research for optimization.

Thiopurines help treat IBD but require genetic testing to avoid side effects.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Combination therapies for androgenetic alopecia work best but can have significant side effects and costs.

Iron deficiency in menstruating women causes many health issues beyond anemia and needs early detection and treatment.

There is a significant need for better-validated quality of life tools in dermatology.

Hair loss is a frequent long-term effect of COVID-19, and oral minoxidil is the most common effective treatment.

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

Some skin medications can have harmful interactions with the COVID-19 drug nirmatrelvir-ritonavir, but not with molnupiravir.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

Botulinum toxin is effective for various skin conditions, but more research and awareness of side effects are needed.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Ashwagandha may improve hormone levels and reduce hair loss in non-classical adrenal hyperplasia.