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This study identified elevated CD25 on secreting CD4 regulatory T cells as a genetic risk factor for androgenetic alopecia, with certain plasma proteins acting as mediators in this causal relationship.

This study found that frequent consumption of sweetened tea drinks is linked to an increased risk of female androgenetic alopecia, with the risk further heightened by late bedtimes, but sleep behavior rather than sugar intake mediates the association.

This review discusses how regulatory T cells, known for their immunosuppressive role, also produce repair mediators critical for tissue repair and regeneration, acting on non-immune cells in tissue-specific contexts, and highlights areas for future research in tissue repair, fibrosis, and cancer.

In this chapter, researchers discuss how microRNAs (miRNAs) interact with vitamin D signaling, highlighting their emerging role as mediators in vitamin D-regulated disorders and their potential for developing miRNA-based clinical applications.

This study observed an association between intense itching in anterior chest keloids and an increased density of nerve fibers in the epidermis, alongside elevated expression of the pruritus mediator substance P, though no difference was found in Langerhans cells related to pruritus, location, or region.

This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.

This study found that administering spironolactone or canrenone to castrated male rats significantly decreased the availability of cytoplasmic androgen receptor binding sites, suggesting canrenone mediates spironolactone's antiandrogenic effects in skin.

This study found that self-stigma is common among alopecia areata patients, with 85% experiencing it to some degree, and that factors like increased social support and illness acceptance correlate with lower stigmatization levels, while helplessness correlates with higher levels.

This review discusses Amphiregulin (AREG) as a potential target for treating fibrotic disorders and cancer, highlighting its role in disease progression and promising results in preclinical studies and early trials.

This review highlights the potential of amphiregulin as a therapeutic target, noting its role in both fibrotic and malignant diseases, and discusses promising early findings but reports no new clinical results.

This study found that blocking the chemokine CXCL12 in a testosterone-induced mouse model of androgenetic alopecia restored hair regeneration and reduced fibrosis and immune alterations.

This study found that exosomes derived from hypoxia-conditioned mesenchymal stem cells modulated inflammatory biomarkers by decreasing CXCL12 and increasing IL-10 expression in a DHT-induced androgenic alopecia mouse model, indicating potential for treating hair loss through immunoregulation.

This study found that oral administration of Curcuma longa L. extract in castrated rats with benign prostate hyperplasia reduced pro-inflammatory cytokine expression, suggesting a potential anti-inflammatory effect.

This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.

This review examines the mixed evidence on mast cells as regulators of skin fibrosis and highlights existing gaps in the scientific understanding, reporting no new experimental results.

This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.

Stress may affect hair growth by influencing hair follicle development and could contribute to hair loss.

This study reports that mast cells are not only passive participants but also key regulators in skin aging, and their role as both protectors and accelerators of aging suggests they could be promising therapeutic targets for skin aging interventions.

This study found that finasteride may improve pulmonary and hepatic immune responses in mice when administered after major trauma and hemorrhage.

In a study of 435 undergraduate medical students, researchers found that rejection sensitivity was linked to increased loneliness and problematic internet use, with loneliness mediating this relationship and self-control moderating its impact, highlighting pathways and conditions that could inform interventions.

This review discusses how regulatory T cells may also promote tissue regeneration through specialized pathways, in addition to their traditional role in maintaining immune tolerance, but reports no new experimental results.

This study found that scalp micropigmentation significantly improved psychological well-being among adults by enhancing appearance satisfaction and perceived physical attractiveness, but not through a direct relationship with psychological well-being itself.

This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.

The researchers reported that in patients with contact dermatitis, certain immune and skin barrier biomarkers, such as Th-cell mediated markers and cholesterol derivatives, may help distinguish between irritant and allergic subtypes, suggesting potential for improved diagnosis through integrated analysis.

In this study, exposure to e-cigarette vapor was reported to trigger the release of proinflammatory cytokines IL-6, IL-8, and IL-10, which could contribute to dermatological issues.

This review discusses the role of adipose tissue as an endocrine organ affecting skin physiology and suggests a complex interaction between adipocytes and the skin as part of the broader endocrine system, but provides no new clinical results.

In this study, Maas-Szabowski and Szabowski revealed that c-Jun and JunB transcription factors, as well as granulocyte macrophage-colony stimulating factor, regulate human keratinocyte growth and differentiation in fibroblast–keratinocyte interactions.

This article reviews the essential role of vitamin D in bone health and its various clinical applications but reports no new clinical findings.

This review discusses recent advances in understanding the molecular landscape of the dermal papilla, particularly focusing on Blimp1's role in hair follicle development and potential therapeutic targets for hair regeneration, but presents no new clinical results.

Laser treatment boosts hair growth by activating a key growth factor.