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This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.

This study suggests that mechanical tension significantly impacts lymphocyte function, and that a complete lymphocyte population is essential for effective wound healing and reducing inflammation.

In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.

In this study, researchers observed that after mesenchymal cell division in mouse and chicken embryonic skin, elevated migration speed and persistence for 180 minutes contribute to mesenchymal dispersal and preferential recruitment to dermal condensates.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.

In this study, researchers observed that knocking out KCNQ3 in mice increased firing frequencies in response to stimuli, particularly at slow mechanical indentation velocities, indicating a role in mechanosensory neuron sensitivity.

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

This review explores the biomechanical factors and signaling systems, like Wnt, involved in the pathophysiology of psoriatic nail lesions and reports no new results.

Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.

Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.

This study found that maintaining tension-force balance in a human skin equivalent improved characteristics of skin homeostasis and structure, suggesting potential as an alternative to animal models for studying skin physiology.

This study experimentally validated Lockhart's viscoplastic framework for tip growth in Arabidopsis root hairs by demonstrating alignment with observed growth rates and estimating yield turgor pressure and cell wall viscosity, offering a methodology adaptable to other species and conditions.

This study found that Cupiennius salei spiders have specialized mechanosensitive hairs on their legs that adaptively respond to joint movements during walking, suggesting a proprioceptive function.

In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.

In this study, researchers explored various aspects of the TRPV3 ion channel, including its novel mechanosensitivity to shear stress, and identified novel agonists while investigating how repeated stimulation affects TRPV3 activity, but found no evidence of GPCRs sensitizing the channel.

This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.

Wnt signaling helps regenerate hair follicles in wounds by reducing skin cell sensitivity to mechanical stress.

This study found that human C-tactile afferents respond to hair deflection, suggesting a functionally relevant anatomical relationship to hair follicles similar to that observed in mice.

This study found that targeting connective tissue sheath contraction with an MLCK inhibitor may improve hair growth in androgenetic alopecia by reducing premature hair regression caused by ectopic apoptosis of hair follicle progenitor cells.

This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

This study proposes that the terminal tuft structure in sensory nerve endings, involving Schwann cell processes and axon fingers, potentially plays a role in mechano-electric transduction in rats.

This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.

This review summarizes a 15-year collaboration on the role of synaptic-like vesicles in mechanosensory nerve terminals and suggests potential therapeutic implications for conditions like hypertension and muscle spasticity.

This study found that distinct low-threshold mechanoreceptors innervate different hair follicle types in mice, suggesting that these follicles serve as unique mechanosensory structures in touch perception.

This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.

This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.

In this study, researchers observed that mechanosensory neurons initially develop similar morphologies across different skin regions but diverge post-natally, adapting to the type of skin they innervate, with bone morphogenetic protein signaling crucial for forming Meissner corpuscles in glabrous skin.