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This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.

This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This study found that the transcription factor Meis2 is crucial for the maturation and innervation of sensory neurons responsible for light touch in mice, with its absence leading to reduced touch sensitivity.

This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.

This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.

In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.

This study found that somatosensory axons innervating Merkel cells in adult mouse skin exhibit significant plasticity, influenced by epithelial and neural factors, indicating a complex interaction in maintaining homeostasis.

This study in adult mice found that somatosensory axons innervating Merkel cells in the skin are highly plastic, with significant remodeling in response to epithelial turnover, and that Merkel cells play a role in limiting axonal branching and promoting their maturation.

This study observed a high degree of plasticity in somatosensory axons innervating Merkel cells in mouse skin, finding that both axons and Merkel cells underwent dynamic remodeling, with their interactions influencing axonal branching and maturation.

In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, revealing that both epithelial-neural crosstalk and intrinsic neural mechanisms contribute to axonal patterning and remodeling during epithelial homeostasis.

This study observed that Merkel cells and their associated somatosensory axons in mouse skin exhibit significant plasticity, remodeling dynamically to maintain homeostasis. Axonal branching patterns were notably influenced by Merkel cells, suggesting epithelial-neural interactions play a key role in axonal plasticity and patterning.

In this study, highly dynamic remodeling was observed in mouse somatosensory axons and Merkel cells, indicating that epithelial-neural interactions help maintain homeostatic remodeling, with additional intrinsic neural mechanisms contributing to axonal plasticity.

This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This review article addresses how the TRPV4 ion channel helps cells respond to mechanical and environmental stimuli, discussing its role in calcium signaling crucial for tissue repair and fibrosis across various organ systems, and highlighting potential therapeutic targets from animal and disease models.

This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.

In this study, researchers observed that knocking out KCNQ3 in mice increased firing frequencies in response to stimuli, particularly at slow mechanical indentation velocities, indicating a role in mechanosensory neuron sensitivity.

This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

This study found that Cupiennius salei spiders have specialized mechanosensitive hairs on their legs that adaptively respond to joint movements during walking, suggesting a proprioceptive function.

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

This study found that sphingosine 1-phosphate and its receptor S1PR3 are essential in regulating the acute mechanical pain response, highlighting their role in mechanonociception without affecting responses to innocuous touch or thermal stimuli.

In this study, researchers found that the bioactive lipid sphingosine 1-phosphate and its receptor, S1PR3, are essential for regulating mechanical pain sensitivity in mice.

This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.

In this review, researchers examined advanced sensing technologies and bioelectronic interfaces that could improve understanding of the skin–brain axis, highlighting challenges and strategies for integrating these platforms into models for studying skin and neural interactions.