June 2025 in “ACS Biomaterials Science & Engineering” In this study, researchers developed a new microneedle patch delivery system for minoxidil, which enhanced its controlled release and improved hair growth in mice, potentially offering better treatment outcomes for androgenetic alopecia.
9 citations
,
February 2007 in “JAMA” PCOS is a common inherited condition causing cysts, irregular periods, and increased diabetes risk in women.
8 citations
,
May 2023 in “Gels” This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.
83 citations
,
September 2021 in “Advanced functional materials” This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.
April 2024 in “Cosmetics” This review highlights the use of microneedling devices and patches to deliver cosmetic agents through the skin, noting their applications in skin rejuvenation and safety considerations such as potential skin irritation and infection.
25 citations
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May 2020 in “Aesthetic Surgery Journal” In this systematic review, tSVF-based therapy demonstrated favorable outcomes for various pathologies, including aged skin and osteoarthritis, with low incidence of adverse events, while highlighting the need for further research into optimal protocols and mechanisms of action.
2 citations
,
February 2023 in “Shiraz E-Medical Journal” In this study, low-level laser therapy significantly improved the mechanical strength of bone at tooth extraction sites in rats, while neither platelet-rich plasma alone nor combined with laser affected mechanical strength or calcium content.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
86 citations
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June 2017 in “Stem cell investigation” This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.
43 citations
,
December 2013 in “Stem Cells” Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.
4 citations
,
January 2007 in “Sen'i Gakkaishi” This study found that permanent wave treatment accelerates hair degradation after protease exposure, showing significant morphological differences compared to untreated hair and linked to damage from Alpha-helical region denaturation.
1 citations
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May 2022 in “Frontiers in medicine” This study found that topical application of metformin significantly enhanced skin regeneration in mechanically stretched skin in rats, likely by boosting the proliferation of skin-derived stem cells.
February 2024 in “Universal Library of Innovative Research and Studies” In this study, researchers found that the primary cause of slippage and detachment of keratin capsules in hair extensions is the re-contamination by oily residues from the hairdresser's hands, rather than the use of hair care products like masks or conditioners.
24 citations
,
September 2014 in “Drug Delivery” This study found that pretreating mouse skin with microneedles significantly enhanced the hair growth inhibitory effect of eflornithine cream, likely by improving its skin permeation.
305 citations
,
July 2016 in “International Journal of Biological Macromolecules” This review describes the roles of polysaccharides in antitumor, antiviral, and anti-inflammatory activities and introduces methods for their isolation and purification, reporting no new research results.
163 citations
,
April 2019 in “Nature Communications” This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.
140 citations
,
August 2011 in “Biomaterials” This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.
41 citations
,
May 2018 in “Nutrition and healthy aging” This study suggests that age-related changes in skin elasticity reduce its stability against wrinkling, and anti-aging strategies should focus on addressing elastic mismatches between skin layers.
24 citations
,
January 2018 in “Journal of Visualized Experiments” In this study, 23 patients with androgenetic alopecia were treated with non-activated autologous platelet-rich plasma (A-PRP) administered through interfollicular injections, but the abstract provides no results of the treatment's effectiveness.
22 citations
,
November 2018 in “Brazilian Journal of Pharmaceutical Sciences” This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.
13 citations
,
May 2016 in “International journal of biological macromolecules” This study demonstrated that molecular dynamics simulations of keratin could effectively model the mechanical properties of hair, aligning well with experimental data, especially when conducted in vacuum conditions.
4 citations
,
June 2021 in “Scientific Reports” This study found that examining hair morphology provides deeper insights than classification, suggesting a potential population stratification artefact between hair curvature and cross-sectional shapes in the examined admixed African-European sample.
2 citations
,
February 2024 in “Nature cell biology” In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.
2 citations
,
August 2011 in “InTech eBooks” New methods for growing skin cells can improve skin grafts by building blood vessels within them.
1 citations
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November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study introduced a new high-throughput method for analyzing scalp hair morphology and found that quantifying hair form provides more accurate information than traditional classification based on racial categories, challenging the belief that cross-sectional morphology predicts hair curvature.
June 2026 in “Research Square” This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.
July 2025 in “Frontiers in Bioengineering and Biotechnology” This study reports that despite advancements in tissue engineering and biomaterials, translating laboratory findings into effective clinical treatments for urethral reconstruction remains inadequate due to lack of standardization and short clinical trial follow-ups.
December 2024 in “STUDIES IN ENGINEERING AND EXACT SCIENCES” In this study, solar drying of Punicagranatum was found to be the most effective, achieving a 65.26% drying rate compared to shade and convective drying methods.
December 2023 in “Frontiers in pharmacology” In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.
November 2018 in “Springer eBooks” The document concludes that hair transplant methods are often selected for provider convenience over patient benefit, highlighting the need for less invasive techniques and careful physician involvement for better results.