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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Certain genetic variations in OCT1 may improve insulin sensitivity with metformin in women with PCOS.

Women with nonclassic 21-hydroxylase deficiency can have successful pregnancies through IVF, with certain factors affecting their chances.

Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Hdac1 and Hdac2 help maintain and protect the cells that control hair growth.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

PCOS is a common hormonal disorder in women, causing symptoms like acne and irregular periods, and is managed with medication and lifestyle changes.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

Finasteride exposure harms tadpole reproduction and hormone balance.

Understanding Polycystic Ovary Syndrome (PCOS) and its causes can lead to effective treatments.