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GlossaryExtracellular Matrix Proteins (matrix proteins)

provide structural and biochemical support to surrounding cells

Extracellular Matrix Proteins (ECM Proteins) are a group of molecules secreted by cells that provide structural and biochemical support to the surrounding cells. These proteins, such as collagen, elastin, and fibronectin, form a complex network that helps maintain tissue integrity, facilitates cell communication, and plays a crucial role in wound healing and tissue regeneration.

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The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

44 citations, June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.

research Cartilage Oligomeric Matrix Protein Forms Part of the Connective Tissue of Normal Human Hair Follicles

14 citations, February 2011 in “Experimental dermatology”

A protein called COMP is part of the connective tissue in normal human hair follicles and may be important for hair health.

research Dipeptidyl-Peptidase 4 (DPP4)-Positive Fibroblasts Are Responsible for Secretion of Pro-Fibrotic Matrix Proteins in Human Skin

April 2019 in “Journal of Investigative Dermatology”

DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.

Combination of Media, Biomaterials, and Extracellular Matrix Proteins to Enhance the Differentiation of Neural Stem/Precursor Cells into Neurons

research Combination of Media, Biomaterials, and Extracellular Matrix Proteins to Enhance the Differentiation of Neural Stem/Precursor Cells into Neurons

25 citations, April 2012 in “Acta Biomaterialia”

Using certain small proteins with a growth factor and specific materials can increase the creation of neurons from stem cells.

research Disulfide Cross-Linked Network Structure of Intermediate Filament and Matrix in Hair and Wool Cortices

4 citations, January 2015 in “Sen'i Gakkaishi”

Hair and wool strength is affected by the number and type of bonds in their protein structures, with hair having more protein aggregates than wool.

research Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2

22 citations, June 2018 in “Journal of Neuroinflammation”

Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.

research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

2 citations, September 2023 in “International journal of molecular sciences”

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Epithelial Loss of Mitochondrial Oxidative Phosphorylation Leads to Disturbed Enamel and Impaired Dentin Matrix Formation in Postnatal Developed Mouse Incisor

research Epithelial Loss of Mitochondrial Oxidative Phosphorylation Leads to Disturbed Enamel and Impaired Dentin Matrix Formation in Postnatal Developed Mouse Incisor

3 citations, December 2020 in “Scientific reports”

Mitochondrial problems in tooth cells lead to bad enamel and dentin development in mice.

research Age-Related Changes in Human Scalp Extracellular Matrix: Implications for the Hair Follicle

September 2017

Older women's scalp cells show changes that could contribute to hair thinning.

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

116 citations, April 1986 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin is a protein in hair follicles that helps form hair filaments.

research Properties of Partially Extracted Hairs and Their Degradability by Proteases

January 2007 in “Sen'i Gakkaishi”

Mf-rich hair degrades more than Ma-rich hair, especially with Proteinase K.

Understanding the Effect on Hair Fibers of Coloring and Bleaching Formulations Using High Pressure Differential Scanning Calorimetry

research Understanding the Effect on Hair Fibers of Coloring and Bleaching Formulations Using High Pressure Differential Scanning Calorimetry

January 2007

Hair coloring and bleaching can permanently break down hair protein and temporarily change its properties.

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

research In Vitro and Ex Vivo Examination of Topical Pomiferin Treatments

10 citations, February 2014 in “Fitoterapia”

Pomiferin may improve skin and hair by increasing important protein production.

research Pomiferin: A Potent Stimulant of Extracellular Matrix Proteins

December 2015 in “Focus on catalysts”

Pomiferin may improve skin and scalp health by boosting important protein expression.

Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

research Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.

research Chapter 4: Cytomechanics of Hair

19 citations, January 2009 in “International review of cell and molecular biology”

Hair's strength and flexibility come from its protein structure and molecular interactions.

research Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis

25 citations, April 2021 in “The EMBO Journal”

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

research Action of Thioglycolic Acid and L-Cysteine on Disulfide Cross-Links in Hair Fibers During Permanent Waving Treatment

18 citations, January 2008 in “Sen'i Gakkaishi”

Thioglycolic acid and L-cysteine change hair structure differently during perms, affecting hair strength and curling efficiency.

research Intermolecular Disulfide Cross-Linked Structural Change Induced by Permanent Wave Treatment of Human Hair with Thioglycolic Acid

1 citations, December 2012 in “PubMed”

Permanent wave treatment with thioglycolic acid changes hair structure by altering disulfide bonds.

research Effects of Non-Ablative Fractional Erbium Glass Laser Treatment on Gene Regulation in Human Three-Dimensional Skin Models

24 citations, January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

research Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging

14 citations, December 2020 in “Journal of Investigative Dermatology”

Aging causes changes in the scalp that can affect hair growth and lead to older-looking hair in women.

research A New Strategy to Modulate Alopecia Using a Combination of Two Specific and Unique Ingredients

7 citations, March 2013 in “PubMed”

A new hair loss treatment with two unique ingredients improved hair growth.

research Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing

238 citations, March 2013 in “Development”

Fat cells help recruit healing cells and build skin structure during wound healing.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations, August 2011 in “Biomaterials”

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations, January 2013 in “Expert Opinion on Biological Therapy”

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.