45 citations
,
October 2009 in “Dermatology” This study observed that long-term recombinant interferon alpha-2b therapy was associated with considerable hair loss in some patients, indicated by a telogen effluvium pattern on trichograms.
43 citations
,
August 2010 in “Expert Opinion on Investigational Drugs” This review explores the potential of selective 11β-HSD1 inhibitors to improve insulin sensitivity in type 2 diabetes, emphasizing the need for more clinical research and reports no new clinical results.
40 citations
,
August 2006 in “Current Drug Safety” This article reviews how various drugs may cause hair loss, stimulate growth, or alter hair characteristics, but reports no new clinical results; drug-induced hair loss is typically reversible.
39 citations
,
September 2012 in “Human Reproduction” This study found that specific SHBG gene variants, rs727428 and rs6259, were associated with PCOS in Mediterranean women, although the associations were relatively weak and do not indicate a causative role.
37 citations
,
December 2007 in “International journal of clinical practice” This review discusses the definition, pathogenesis, diagnosis, and management of hirsutism and reports no new clinical results.
37 citations
,
May 2003 in “Journal of Consumer Marketing” This review discusses consumers' positive attitudes towards direct-to-consumer pharmaceutical advertising, highlighting its impact on patient engagement despite physicians' mixed opinions on its influence on the doctor-patient relationship.
35 citations
,
June 2017 in “Pharmacognosy Journal” This study found that alkaloids isolated from Eclipta alba leaves showed increasing antimicrobial activity with higher concentrations, particularly against S. aureus and E. coli, suggesting potential for developing antimicrobial agents.
34 citations
,
September 1985 in “Contact Dermatitis” Minoxidil can cause skin irritation like eczema and rash in some users.
30 citations
,
March 2015 in “Clinical Endocrinology” This study found that late adolescent and young women with clinical hyperandrogenism, including PCOS, experienced higher psychological distress and impaired well-being compared to their healthy peers.
28 citations
,
July 2007 in “Development” In this study, inactivating the TAF4 subunit of transcription factor TFIID in mouse epidermis disrupted gene expression linked to skin and hair function, and increased tumor risk.
27 citations
,
October 2020 in “Experimental Dermatology” This study found that both extensive grey hair and alopecia were independently associated with increased COVID-19 severity among survey respondents in Brazil.
27 citations
,
April 2013 in “Reviews in endocrine and metabolic disorders” The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
27 citations
,
February 2009 in “Autoimmunity Reviews” This study describes the development of the EUSCLE Core Set Questionnaire for cutaneous lupus erythematosus, designed to standardize data collection, facilitate epidemiological analysis, and guide diagnostic and therapeutic strategies across European centers.
26 citations
,
January 2013 in “BMJ Open” This meta-analysis reports that vertex baldness is associated with an increased risk of coronary heart disease, particularly in younger men, while no significant link was found for frontal baldness.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
25 citations
,
April 2008 in “Archives of Dermatological Research” This study found that transplanted microencapsulated dermal papilla cells in rat footpads can regenerate hair follicles and sebaceous gland structures, suggesting a potential substitute for fresh dermal papillae cells.
25 citations
,
March 2000 in “Journal of Endocrinological Investigation” Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
22 citations
,
January 2017 in “Skin appendage disorders” This research analyzed 72 primary scarring alopecia cases in a Barcelona hospital, finding that the majority involved women, with a lymphocytic infiltrate and subacute onset in many cases, leading to stable disease, while neutrophilic cases had more acute episodes.
22 citations
,
December 2013 in “Molecular biology of the cell” This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.
22 citations
,
January 1985 in “Annals of Internal Medicine” Minoxidil in breast milk may harm nursing infants.
21 citations
,
November 2009 in “Dermatologic Clinics” This review discusses hair abnormalities in various epidermolysis bullosa subtypes and reports no new clinical findings.
19 citations
,
November 2021 in “Lupus Science & Medicine” This study found that Black patients with discoid lupus erythematosus had significantly worse CLASI damage scores and higher odds for dyspigmentation, scalp involvement, and scarring alopecia compared to non-Black patients.
18 citations
,
January 2020 in “Journal of the European Academy of Dermatology and Venereology” This study identified trichoscopy as a key diagnostic tool for erosive pustular dermatosis of the scalp and suggested high-potency steroids or tacrolimus as effective first-line treatments.
18 citations
,
May 2016 in “Annals of Medicine” This paper reviews seven major systemic causes of hair loss and provides a clinical evaluation framework but reports no new experimental results.
18 citations
,
May 2013 in “Cutaneous and Ocular Toxicology” This study suggests that cutaneous adverse reactions to bortezomib and lenalidomide are more frequent than reported, impacting patients' quality of life and may require dermatological consultation for proper management.
17 citations
,
May 2012 in “Clinical Endocrinology” This study found that surgical normalization of testosterone in hyperandrogenic women with ovarian androgen-secreting tumors did not significantly change body weight or insulin sensitivity after 12 months.
14 citations
,
January 2015 in “Skin appendage disorders” This case report details two women with female pattern hair loss who experienced severe scalp allergic contact dermatitis from minoxidil, one due to the active ingredient and the other due to the vehicle.
12 citations
,
January 2016 in “Skin appendage disorders” This study reports that women receiving periodic injections of botulinum toxin type A for forehead wrinkles may experience frontal alopecia, with progressive hairline recession observed in the cases studied.
12 citations
,
January 2005 in “Journal of Cosmetic Dermatology” This review discusses the natural progression of androgenetic alopecia and potential factors influencing its long-term prognosis, reporting no new clinical results.
10 citations
,
October 2024 in “Dermatology Practical & Conceptual” This study found that dupilumab's effects on alopecia areata varied depending on patients' immune profiles, with Th2-skewed females seeing improvements and Th1-driven males experiencing worsening.