Search

for
Search:

Did you mean MAPK?

GlossaryExtracellular Signal-Regulated Kinase (MAPK)

protein that transmits signals from cell surface to DNA

Extracellular Signal-Regulated Kinase (ERK) is a type of protein kinase that plays a crucial role in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It helps transmit signals from the cell surface to the DNA in the cell nucleus, influencing processes like cell division, differentiation, and survival. This pathway is important in various biological functions and can be implicated in conditions like cancer and alopecia when dysregulated.

Related Terms

Sort by

Research

30 / 1000+ results

Melatonin Regulates the Mitogen-Activated Protein Kinase Pathway via the CircMPP5-miR-211-MAPK3 Axis to Induce Secondary Hair Follicle Differentiation and Development in Newborn Cashmere Goat Kids

research Melatonin Regulates the Mitogen-Activated Protein Kinase Pathway via the CircMPP5-miR-211-MAPK3 Axis to Induce Secondary Hair Follicle Differentiation and Development in Newborn Cashmere Goat Kids

1 citations, October 2022 in “Research Square (Research Square)”

Melatonin helps improve Cashmere goat hair quality by promoting hair follicle growth through a specific cell signaling pathway.

GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

research GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

5 citations, January 2021 in “Journal of Saudi Chemical Society”

Watercress oil may promote hair growth by activating specific receptors.

research Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5

1 citations, April 2023 in “Journal of Animal Science and Biotechnology”

Melatonin helps grow more secondary hair follicles in young goats, improving cashmere production.

research Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

research Elucidating the Anti-Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo

6 citations, May 2022 in “Aging”

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

research Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of Dermal Papilla in Androgenetic Alopecia

June 2024 in “Research Square (Research Square)”

Increased cell death and reduced cell growth in hair follicles contribute to baldness.

research Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review

343 citations, December 2008 in “Endocrine Reviews”

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

research Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells

92 citations, August 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

research Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

39 citations, October 2013 in “Plastic and Reconstructive Surgery”

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid

31 citations, October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

25 citations, February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

25 citations, September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

research Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production

22 citations, April 2020 in “Scientific reports”

Changthangi goats have specific genes that help produce Pashmina wool.

research Elevated Fasting Insulin Is Associated With Cardiovascular and Metabolic Risk in Women With Polycystic Ovary Syndrome

17 citations, May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews”

High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.

research Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients

12 citations, November 2020 in “Journal of Dermatological Science”

Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.

research Identification of MicroRNAs Involved in Growth Arrest and Cell Death in Hydrogen Peroxide-Treated Human Dermal Papilla Cells

12 citations, April 2014 in “Molecular Medicine Reports”

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

research Impact of Taxol on Dermal Papilla Cells: A Proteomics and Bioinformatics Analysis

9 citations, October 2011 in “Journal of proteomics”

Taxol damages hair growth cells, causing hair loss.

Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

research Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

5 citations, January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

research Estrogen Modulates Mesenchymal-Epidermal Interactions in the Adult Nipple

4 citations, March 2017 in “Development”

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

research In-Silico Cardiac Aging Regulatory Model Including MicroRNA Post-Transcriptional Regulation

3 citations, June 2017 in “Methods”

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

research Analysis Of The Function Of ADAM17 In IRhom2 Curly-Bare And Tylosis With Esophageal Cancer Mutant Mice

2 citations, June 2023 in “Journal of cell science”

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

research A Computationally Inferred Regulatory Heart Aging Model Including Post-Transcriptional Regulations

1 citations, December 2016

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

research Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Cells

September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

FOL-026 peptide can help repair blood vessels and promote growth, offering potential treatment for vascular diseases.

research Chitosan Stimulates Root Hair Callose Deposition and Inhibits Root Hair Growth

July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Chitosan slows root hair growth and causes a buildup of callose at low concentrations, but at high concentrations, it only inhibits growth without callose buildup.

research Integrated miRNA-mRNA Analysis Reveals Regulatory Pathways Underlying the Curly Fleece Trait in Chinese Tan Sheep

17 citations, May 2018 in “BMC genomics”

Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

8 citations, March 2015 in “Molecular Medicine Reports”

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

research Quercetin and Polycystic Ovary Syndrome

6 citations, December 2022 in “Frontiers in Pharmacology”

Quercetin may help improve symptoms of polycystic ovary syndrome.

research Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome

3 citations, May 2023 in “Biomedicines”

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations, July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.