34 citations
,
March 2020 in “BMC plant biology” This study found that cotreatment with graphene oxide and indole-3-acetic acid significantly inhibited root development in Brassica napus, with the inhibition increasing as indole-3-acetic acid concentration rose.
January 2025 in “Fitoterapia” This study reviewed literature on signaling pathways and concluded that these pathways are crucial pharmacological targets, influencing the mechanisms of drugs used in neurological, cardiovascular, and oncological treatments to correct signal transmission disturbances.
July 2024 in “Frontiers in Pharmacology” This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.
6 citations
,
May 2022 in “Frontiers in physiology” This study suggests that an in ovo injection of CHIR-99021 promoted feather growth and follicle development in goose embryos by activating the Wnt signaling pathway.
68 citations
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May 2011 in “European Journal of Dermatology” Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.
25 citations
,
August 2017 in “Animal Biotechnology” This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.
March 2026 in “Dermatology and Therapy” This study identified distinct plasma miRNA profiles in alopecia areata that may aid in diagnosis and therapy, but further validation is needed to confirm these exploratory findings.
45 citations
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April 2013 in “Cell Transplantation” In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.
31 citations
,
January 2007 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that c-Jun is essential for vitamin D receptor expression, and the vitamin D receptor inhibits c-Jun-dependent cell death through non-classical mechanisms independent of vitamin D3.
18 citations
,
July 2021 in “Molecular Medicine Reports” This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.
14 citations
,
June 2018 in “Frontiers in pharmacology” In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.
January 2026 in “Food Science and Human Wellness” This research examined krill oil's effects on benign prostatic hyperplasia and found that it inhibited the growth of prostate cells in vitro and reduced prostate size and weight in a BPH rat model, suggesting potential as a prophylactic or therapeutic agent for BPH.
43 citations
,
September 2017 in “Lasers in Surgery and Medicine” This study found that LED light irradiation induced proliferation and migration of human outer root sheath cells, potentially through the stimulation of the Wnt/β-catenin and ERK signaling pathways.
28 citations
,
May 2018 in “Scientific reports” This study found that exercise decreases the expression of 5αR1, thereby enhancing the PI3K/AKT signaling pathway in PCOS rats.
18 citations
,
April 2019 in “Archives of Dermatological Research” This study found that bovine lactoferrin promotes hair growth in mice by enhancing dermal papilla cell proliferation through the Erk/Akt and Wnt signaling pathways.
14 citations
,
September 2018 in “International Journal of Molecular Sciences” This study found that mackerel-derived fermented fish oil extract and its component DHA promote hair growth by activating anagen pathways in dermal papilla cells.
10 citations
,
May 2020 in “Journal of Dermatological Treatment” This study found that combining microneedling with 5% minoxidil improved hair growth in Chinese men with androgenetic alopecia, possibly through activating the Wnt/β-catenin signaling pathway.
10 citations
,
May 2019 in “BMC Complementary and Alternative Medicine” This study found that Bacillus/Trapa japonica fruit ferment filtrate extracts enhanced human hair follicle dermal papilla cell proliferation through the Akt/ERK/GSK-3β signaling pathway, suggesting potential benefits for alopecia treatment.
May 2026 in “Scientific Reports” In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.
1 citations
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May 2017 in “InTech eBooks” This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.
144 citations
,
November 2020 in “Frontiers in immunology” This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.
November 2024 in “Journal of Translational Internal Medicine” This study found that umbilical cord mesenchymal stem cell-derived exosomes improved hair growth in mice with androgenetic alopecia by promoting hair follicle stem cell stemness through the RAS/ERK pathway, suggesting a potential new treatment strategy for this condition.
30 citations
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April 2020 in “Stem Cell Research & Therapy” This study found that the PI3K-Akt signaling pathway is essential for regenerating new hair follicles when epidermal stem cells and skin-derived precursors are combined, suggesting potential therapeutic applications for hair regeneration.
29 citations
,
January 2021 in “Translational Psychiatry” This study found that certain gene sets, including those involved in ligand-gated ion channel signaling and cell adhesion, are associated with Tourette syndrome, suggesting a potential neurobiological basis for the disorder.
26 citations
,
April 2019 in “Advances in wound care” This study found that tannic acid accelerated wound healing in rats by modulating inflammatory cytokines, increasing growth factors, and activating the Erk 1/2 pathway.
119 citations
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November 2014 in “Trends in Cell Biology” This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.
28 citations
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May 2019 in “Life Sciences” This study found that ginsenoside Rb1 promoted the growth of mink hair follicles and dermal papilla cells, potentially through activating the PI3K/AKT/GSK-3β signaling pathway.
December 2025 in “ADMET & DMPK” This review synthesizes recent research to propose a precision framework for treating androgenetic alopecia and alopecia areata based on genetic insights and pathway biology, highlighting the roles of androgen-receptor signaling, immune dysregulation, and emerging therapies like regenerative medicine and AI-assisted diagnostics.
January 2024 in “Research Square (Research Square)” This study identified key genes related to ischemic stroke through the ferroptosis pathway and highlighted the potential role of specific traditional Chinese medicines in regulating associated biological processes.
20 citations
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June 2010 in “Genes and Immunity” This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.