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Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Fat-related cells are important for initiating hair growth.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Polysaccharides have many health benefits and are used in drugs, but isolating and purifying them is complex and requires careful methods.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Different types of skin cells play specific roles in development, healing, and cancer.

Targeted cancer therapies often cause serious skin problems that need careful management.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Stem cell niches support, regulate, and coordinate stem cell functions.