26 citations
,
January 1982 in “Hormone Research” This study found that plasma androgen levels tend to be lower than normal in patients with multiple pituitary hormone deficiencies, particularly those with ACTH deficiencies, and that human growth hormone treatment does not affect adrenal androgen secretion.
25 citations
,
November 2020 in “Proceedings of the National Academy of Sciences” This study found that the HoxC gene cluster plays a critical role in the development of ectodermal organs, including hair and nails, with mammalian-specific enhancers increasing transcription levels during development.
24 citations
,
September 2018 in “Lasers in Surgery and Medicine” This study shows that multiphoton microscopy can non-invasively distinguish between scarring and non-scarring alopecia by identifying certain morphological features, but further research is needed to confirm its clinical utility.
23 citations
,
May 2017 in “Journal of the American Academy of Dermatology” This study found that patients with frontal fibrosing alopecia had lower epidermal melanocyte counts and reduced epidermal thickness compared to lichen planopilaris patients and controls, suggesting a link with hypopigmentation.
23 citations
,
December 2013 in “British Journal of Dermatology” This study identified a new PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.
23 citations
,
May 2009 in “International Journal of Dermatology” In this study, no association was found between the AR gene and type II androgenetic alopecia in Egyptian women, suggesting it is not a useful biomarker for predisposition.
22 citations
,
August 2016 in “European Eating Disorders Review” This study found that female patients with anorexia nervosa had lower hair cortisol concentration compared to healthy and psychiatric controls, which may be influenced by body mass index rather than anorexia-related endocrine changes.
22 citations
,
August 2012 in “PubMed” Adequate zinc and iron intake may reduce hair loss after bariatric surgery.
21 citations
,
June 2011 in “Journal of child neurology” This study found that while serum zinc levels were lower in children treated with valproic acid or carbamazepine than in healthy controls, zinc, biotin, and biotinidase enzyme activity remained within normal ranges and unaffected by these treatments.
20 citations
,
April 2023 in “The Journal of Urology” This study found that two injections of platelet-rich plasma were safe but no more effective than placebo in treating mild to moderate erectile dysfunction.
19 citations
,
March 1990 in “Journal of Cardiovascular Pharmacology” Minoxidil affects rat fluid dynamics, altering pressure and circulation, improving blood flow and hair growth.
17 citations
,
August 2002 in “AIDS” This study observed that patients undergoing indinavir/ritonavir therapy for HIV-1 frequently experienced reversible alopecia, likely due to retinoid-like effects, but these were independent of other retinoid-like skin manifestations.
16 citations
,
March 2022 in “Journal of Clinical Medicine” In this observational study, researchers found that mini-pulse oral corticosteroids effectively reduced hair loss in alopecia areata patients who did not respond to topical therapies, though early-onset patients and those with hypothyroidism were less likely to benefit.
16 citations
,
January 2019 in “Aging” This study found that transgenic mice expressing a mutant CYLD protein lacking deubiquitinase function showed signs of premature aging and spontaneous tumor development, likely due to over-activation of specific molecular pathways and chronic inflammation.
16 citations
,
May 2009 in “Journal of child neurology” In this study, valproic acid treatment did not significantly affect serum biotinidase enzyme activity in children, but was associated with hair loss in some patients, which resolved with biotin supplementation.
15 citations
,
September 2021 in “Journal of Clinical Medicine” This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects.
15 citations
,
July 2011 in “Americanae (AECID Library)” In this study, women with severe hair loss after bariatric surgery had lower zinc intake compared to those with mild hair loss, suggesting a possible link between zinc consumption and hair loss severity.
15 citations
,
January 1998 This study found that repeated cycles of wetting and blow-drying hair fibers can cause cracks in the hair cuticles, particularly among individuals who frequently blow-dry their hair.
14 citations
,
April 2023 in “International Journal of Molecular Sciences” In a study using female Wistar rats, the researchers found that a liquid allantoin-enriched pectin hydrogel significantly improved wound healing, achieving a 71.43% reduction in healing time and complete wound closure in 15 days.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.
13 citations
,
March 2019 in “Medicina Clínica (english Edition)” This paper reviews the complexities of diagnosing and managing polycystic ovary syndrome, emphasizing the importance of individualized treatment to address symptoms due to hyperandrogenism, ovarian dysfunction, and metabolic issues, but reports no new results.
12 citations
,
January 2024 in “Editora In Vivo eBooks” In this case report, researchers describe dermatophytosis, a fungal skin infection, in an 11-month-old female dog, highlighting the zoonotic nature of the disease that affects both animals and humans, especially in hot and humid climates.
12 citations
,
January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” This case report describes a 67-year-old woman with frontal fibrosing alopecia and her daughter with lichen planopilaris, noting identical HLA D types which suggest a phenotypical link between these conditions.
11 citations
,
April 2020 in “Animals” This study reported that relocation in police horses was associated with elevated hair cortisol concentrations, possibly suggesting altered welfare due to changed surroundings, and that seasonal variations affected both cortisol levels and hair growth.
11 citations
,
March 2019 in “Journal of Medicinal Chemistry” This study reports that synthetic carbohydrate receptors effectively inhibit Zika virus infection in cell cultures by blocking early stages of viral entry.
11 citations
,
March 2018 in “Protoplasma” In this laboratory study, procyanidin B2 inhibited early plant growth and biochemical responses in wheat seedlings treated with lipopolysaccharides from Azospirillum brasilense, suggesting that plant response activation requires LPS recognition by plant cells.
11 citations
,
May 2009 in “Actas Dermo-Sifiliográficas” This review discusses various therapeutic options for alopecia areata and reports no new clinical results; treatments may manage symptoms but do not cure the condition.
10 citations
,
February 2022 in “Epidemiologia” This study reported that about one-third of post-COVID-19 patients experienced long-term symptoms, with women, older individuals, smokers, and those with specific blood groups at higher risk for complications.
10 citations
,
April 2020 in “Journal of surfactants and detergents” This study found that shampoos with sugar-derived surfactants improved hair cleansing properties, were less cytotoxic, and resulted in easier hair combing compared to formulations containing sodium laureth sulfate.
10 citations
,
April 2004 in “Journal of the American Academy of Dermatology” Localized hair growth and fat loss may share a common cause in lupus panniculitis.