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DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Intermediate filaments are crucial for cell differentiation and stem cell function.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Pattern baldness is likely caused by a dominant gene influenced by testosterone levels, making it more common in men.

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Hormones are crucial for regulating body functions and imbalances can lead to health issues.

Dlx3 is essential for hair growth and regeneration.

TCDD disrupts skin stem cells, causing skin issues like chloracne.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Hormone therapies like birth control pills and spironolactone are safe and effective for treating women's adult acne.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

miR-31 regulates hair growth by controlling gene expression in hair follicles.

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.

Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.