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Retinoic acid helps change skin cells and is important for skin development and hair growth.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

A pineal tumor caused a boy's early puberty, which changed from peripheral to central after treatment.

Intravital imaging helps us better understand stem cells in their natural environment and could improve knowledge of organ regeneration and cancer development.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Hair and nail changes can indicate health issues, including cancer and side effects from cancer treatments.

A Japanese bone marrow transplant patient developed a rare skin cancer possibly linked to long-term use of the medication voriconazole.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.

Scalp cooling significantly reduces hair loss in chemotherapy patients.

The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Early diagnosis and treatment with Leuprolide are key for children with precocious puberty.

Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Women with early-onset baldness should be checked for early bone loss, but bone density doesn't change with baldness severity.

Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

A woman with cervical cancer had rare scalp metastasis causing a unique type of hair loss.

Hair loss due to scalp metastasis from breast cancer, known as Neoplastic Alopecia, has a better survival rate than other scalp metastases and requires a biopsy for diagnosis.

Biologic agents can be effective for rheumatic diseases but have risks like infections and require careful monitoring and patient information.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.