November 2025 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” This study examined 16 sporadic trichoblastic tumors and found that although one showed malignant transformation, clinical follow-up revealed no residual or metastatic disease. RNA sequencing indicated a high tumor mutational burden and absence of a UV-related signature, helping to distinguish these tumors from similar growths.
100 citations
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September 2016 in “Clinical transplantation/Clinical transplantation.” This study highlights that prolonged voriconazole use is linked to an increased risk of aggressive cutaneous malignancies like squamous cell carcinoma, necessitating careful monitoring of drug levels to manage adverse effects.
38 citations
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July 1998 in “Journal of surgical oncology” This review discusses acquired hypertrichosis lanuginosa, a rare disorder often linked to internal malignancy, and reports no new clinical findings; the authors highlight proposed pathogenic mechanisms for lanugo hair overgrowth.
1 citations
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March 2005 in “Zentralblatt für Gynäkologie” This case report describes a postmenopausal woman with hirsutism and androgenetic alopecia, where imaging ruled out malignancy and selective venous sampling indicated increased testosterone from the right adrenal vein, leading to a recommendation for right adrenalectomy and oophorectomy.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This case study describes a 41-year-old woman with a solitary thyroid nodule who underwent successful right hemithyroidectomy after initial suspicion of malignancy from ultrasound, later confirmed as benign colloid goiter via FNAC, highlighting the importance of thorough evaluation in thyroid conditions.
In this narrative case report, the authors discuss a patient recently diagnosed with an early-stage hematologic malignancy, highlighting her skepticism toward conventional medicine and preference for natural remedies over pharmaceutical treatments.
In this case study, researchers reported the first documented instance of malignant transformation of congenital triangular alopecia into basal cell carcinoma in a 48-year-old woman, underscoring the importance of assessing long-standing alopecic areas for malignancy.
August 2025 in “Frontiers in Immunology” This case report is the first to document the coexistence of bullous pemphigoid, malignant tumors, and alopecia areata in a patient, highlighting the complete resolution of skin lesions with dupilumab and spontaneous hair regrowth without disease-specific treatment.
February 2025 in “American Journal of Medical Case Reports” The case report highlights the diagnostic challenges of low-grade trichoblastic carcinoma, a rare malignant tumor often mistaken for benign lesions, in a 51-year-old female with immunocompromising conditions. Accurate diagnosis relied on histopathological examination, and achieving clear surgical margins was crucial to prevent recurrence.
March 2024 in “BMC cancer” This study reports that high expression of proteins ST14 and TMEFF1 in ovarian cancer correlates with higher tumor malignancy and worse prognosis, and reveals an interaction where ST14 regulates TMEFF1 to promote cancer cell proliferation, migration, and invasion.
January 2024 in “Wiadomości Lekarskie” This paper reviews the development and implementation of CAR-T cell therapy as a significant advancement in treating pediatric hematological malignancies, particularly for children with relapsed or chemotherapy-resistant acute lymphoblastic leukemia, offering renewed remission prospects where conventional methods are ineffective.
This case report describes a 65-year-old postmenopausal woman with hyperandrogenism caused by a non-malignant ovarian Leydig cell tumor, which is a rare cause of virilization.
This article reviews how to properly take a dermatological history and conduct physical examinations for skin rashes and malignancies, discussing commonly used diagnostic tools and the Dermatology Life Quality Index system.
85 citations
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May 2001 in “International Journal of Dermatology” This study observed that infections were the most common skin conditions in Ghana, while malignant and premalignant skin diseases were most common in the UK, highlighting different dermatological needs in each country.
21 citations
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August 2011 in “BMB Reports” This study successfully established an immortalized human dermal papilla cell line that maintains characteristics of original cells without malignant transformation, potentially benefiting hair research.
173 citations
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July 2012 in “British Journal of Dermatology” This study found that the administration of the mutant BRAF inhibitor dabrafenib in patients with metastatic melanoma was associated with various skin lesions, including keratinocytic proliferation that sometimes showed low-grade malignancy features.
36 citations
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November 2000 in “Journal of the American Academy of Dermatology” This case study describes a unique patient with dermatomyositis who exhibited features of pityriasis rubra pilaris and porokeratosis, suggesting markers for malignancy warranting thorough investigation and monitoring.
30 citations
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February 1994 in “Journal of Cutaneous Pathology” This case study highlights that breast cancer may present as alopecia refractory to usual treatments, indicating the need for consideration of underlying malignancy in such cases.
18 citations
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April 2016 in “American Journal of Dermatopathology” This case series highlights that nail clipping can aid in early detection and surgical planning of onychomatrical tumors by distinguishing between benign and potentially malignant growths based on the cavities' average dimensions.
17 citations
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January 2014 in “Journal of Oral and Maxillofacial Pathology” This case report establishes the diagnosis of seborrheic keratosis in an elderly Indian woman based on histopathological examination, highlighting its potential to mimic malignant tumors and emphasizing the importance of differential diagnosis.
14 citations
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December 2010 in “Seminars in Oncology” This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.
10 citations
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April 2014 in “Molecular and Clinical Oncology” This case report describes a 46-year-old male whose alopecia areata preceded and resolved with treatment for stage IVB classical Hodgkin's lymphoma, highlighting AA as a potential indicator of underlying malignancy, although such cases are rare and not well-characterized.
9 citations
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November 2000 in “Journal of the American Academy of Dermatology” This report presents a rare case of a patient with type Wong dermatomyositis who also exhibits clinical and histologic features of porokeratosis, potentially signaling associated malignancies in dermatomyositis patients.
7 citations
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April 2000 in “Archives of Pathology & Laboratory Medicine” This case report documents the first observed cytologic changes, specifically cytoplasmic vacuolization, in finasteride-associated gynecomastia, which should not be misinterpreted as evidence of malignancy.
7 citations
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April 2000 in “Archives of Pathology & Laboratory Medicine” This case report describes the first observed cytologic changes in gynecomastia associated with finasteride therapy, emphasizing that cytoplasmic vacuolization should not be mistaken for malignancy.
5 citations
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March 2017 in “Immunology and Cell Biology” This review discusses recent advances in biomedical imaging for cancer research, particularly highlighting improved imaging tools for studying solid tissue malignancies, and reports no new clinical results.
5 citations
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June 2016 in “University of Zagreb University Computing Centre (SRCE)” This study observed that canine follicular tumors are an uncommon type of skin neoplasia in Croatian dogs, often benign but with a small percentage presenting malignancy, and vary based on the breed's hair growth type.
3 citations
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September 2021 in “JAAD case reports” This review discusses the increased autoimmune events associated with the use of denosumab, a biologic agent for managing postmenopausal osteoporosis and skeletal complications from malignancy, but reports no new data.
3 citations
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June 2021 in “Clinical, Cosmetic and Investigational Dermatology” This study highlights the importance of dermoscopic examinations in accurately diagnosing skin cancer, which can be mistaken for benign seborrheic keratosis, emphasizing the need for trained interpretation to avoid missing malignant lesions.
2 citations
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January 2018 in “Open journal of stomatology” This study found that trichohyalin is expressed in cancerous tongue epithelial cells, while plectin-1 expression may indicate malignancy.