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Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Hormonal imbalances can cause skin and hair problems in women, and treatments that block male hormones can help.

Finasteride caused enlarged breast tissue in a 62-year-old man.

The document discusses various eye conditions and their treatments, including a rare eye cancer in a baby, vision loss from a cancer drug, cataracts from a baldness treatment, a rare skin disorder, and a specific type of eye disease diagnosed with a special imaging technique.

Most pregnant women experience skin darkening and hair changes, with these effects usually going away after giving birth.

Accurate assessment of puberty using Tanner staging is crucial for identifying normal and abnormal development.

The case highlights the complexity of diagnosing high testosterone in older women and the need for thorough testing.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Hormone treatment for transsexual individuals is effective but carries risks like thromboembolic events and mood changes, with most side effects being minor and reversible.

Botox increased hair count in men with baldness and might work by improving scalp blood flow.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Some skin diseases and their treatments can negatively affect male fertility.

New treatments for male hypogonadism are effective and should be personalized.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Caesalpinia bonduc seed extracts may help treat enlarged prostate in rats.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

Gene mutations can cause problems in male genital development.

The foreword introduces a medical issue discussing male hormonal health, treatments, and the effects of conditions like obesity and aging.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

Hirsutism is often caused by high male hormone levels and can be treated with lifestyle changes and medications.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

A baby boy with 13q deletion syndrome had eye cancer, a woman's vision improved after stopping a breast cancer drug, a man developed cataracts from using Propecia, and a rare skin disorder called Lipoid Proteinosis was discussed. Also, a tool called OCT is useful for diagnosing macular diseases.