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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

Current treatments for alopecia show no significant long-term benefits.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Sorafenib helps some advanced cancers alone or with other treatments, but not all, and research continues to improve its use.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Adrenal disorders can cause lasting brain and behavior issues in children.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Combination therapy improves urinary flow and reduces residual urine, but needs better stent design.

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

Mesotherapy might help reduce fat in specific areas for those close to their ideal weight, but more research and care are needed to ensure safety.

Potassium channel openers show promise for treating heart disease and other conditions, but more research is needed to fully understand their effects and safety.

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

Consider benefits and risks of new alopecia treatments for safety.

Women have a higher risk of blood clots from hormonal factors and need careful treatment, especially during pregnancy.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Tumescent liposuction is safe and effective for different cosmetic surgeries if done within recommended limits.

Low testosterone in men is a risk factor for a specific heart rhythm issue, and testosterone treatment may help prevent it.

Vogt-Koyanagi-Harada disease can develop during interferon therapy for chronic hepatitis C.

Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.

Long COVID patients have more health issues than non-infected people.