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In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

This study highlights emerging research on lactate's biological roles in skin health, emphasizing its function as a signaling molecule that regulates skin barrier and immunity, and notes its therapeutic potential for skin conditions such as tumors and inflammatory diseases.

This study found that blocking the chemokine CXCL12 in a testosterone-induced mouse model of androgenetic alopecia restored hair regeneration and reduced fibrosis and immune alterations.

This study found that oral administration of Flammulina velutipes polysaccharide reduced tumor volume and improved survival in mice by modulating macrophage polarization and enhancing antitumor immune responses.

In this study, researchers found significant links between specific metabolic reprogramming-related genes and alopecia areata risk, highlighting increased SQSTM1 expression in affected hair follicles compared to healthy ones.

This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.

This study found that intrinsic feedback loops are crucial for maintaining the function of human dermal papilla cells during hair growth, highlighting the importance of autocrine signaling and niche reprogramming for advancing hair follicle biology and regenerative therapies for hair loss.

This study found that the protein p63 requires morphogenetic signals to regulate gene expression effectively during skin cell differentiation, highlighting its complex role in therapeutic reprogramming for conditions like epidermolysis bullosa.

In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.

This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.

New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.

In this study, a pH-responsive microneedle patch was developed, showing potential in rat models for treating spinal cord injuries by reducing inflammation, promoting nerve regeneration, and supporting neurogenesis, which contributed to improved motor and neurological recovery.

This review explores the potential of periodontal ligament stem cells for regenerative therapy in periodontium, despite challenges due to their rarity, and reports no clinical results.

This chapter reviews the presence and roles of stem cells in various body systems, focusing on their lifelong function in animals and humans, and reports no new experimental findings.

This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.

This review explores the mechanism and potential applications of wound-induced hair follicle neogenesis but reports no new clinical results, highlighting the need for further research in hair regeneration therapies.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.

Lung immune cells can be trained to better fight infections after a virus.

This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.

This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.

This study proposed a new approach to combat leishmaniasis by targeting host proteins rather than the parasite itself, identifying eight existing drugs as potential treatments despite not having been previously tested on leishmaniasis.

This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.

This scoping review identifies various pharmacological agents and five key mechanistic strategies being studied in vivo to mitigate multi-organ toxicity caused by cytarabine, with apraglutide and N-acetylcysteine highlighted as promising candidates for clinical application.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This study found that MSN-ceria nanomaterial accelerates cutaneous wound healing in rat models by reducing ROS levels and promoting collagen deposition, leading to improved tissue regeneration without significant scarring.

This review highlights the promising potential of using nanomedicine-based immunotherapy in tissue regeneration, detailing recent advances in nanocomposite biomaterials and the modulation of immune responses to create optimal environments for tissue repair.

In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.

This study reviewed the challenges of delivering nucleic acids for gene therapy, highlighting the limitations of non-viral vehicles and exploring bioinspired strategies using cell membrane camouflage for improved delivery efficacy.

This review discusses the use of bioactive glass in skin tissue repair and highlights its potential to aid wound healing through effects on inflammatory cells and tissue regeneration, but reports no new experimental findings.