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The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

Apoptosis is crucial for healthy skin and treating skin diseases.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

Both mouse and rat models are effective for testing alopecia areata treatments.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

Prolactin may be important for skin growth and immune function.