Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.

This study found that specific SHBG gene variants, rs727428 and rs6259, were associated with PCOS in Mediterranean women, although the associations were relatively weak and do not indicate a causative role.

This review discusses the potential of drugs targeting the JAK/STAT pathway for dermatological diseases and outlines a protocol to assess existing evidence, reporting no new clinical results.

This study found that the prevalence of hyperprolactinaemia in healthy premenopausal female blood donors is low and not affected by hormonal contraceptive use, with stress-related factors being the most common cause.

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.

In this study, researchers observed that alterations in scalp microbiota might be linked to inflammation associated with alopecia areata, but it's unclear if these microbiota changes cause or result from hair loss, necessitating further investigation into their causal relationship and mechanisms.

This meta-analysis involving over 3.7 million patients found that diabetes mellitus is associated with a reduced risk of developing prostate cancer, although significant heterogeneity exists among studies; however, a family history of prostate cancer was linked to a higher risk.

This study identified distinct plasma miRNA profiles in alopecia areata that may aid in diagnosis and therapy, but further validation is needed to confirm these exploratory findings.

This study conducted a meta-analysis of gene expression data from alopecia areata patients, identifying 5109 differentially expressed genes and highlighting enriched pathways like JAK-STAT signaling, providing insights into the disease's pathogenesis and potential treatment targets.

This study observed distinct plasma miRNA profiles in alopecia areata, identifying several miRNAs downregulated in both mild and severe forms; machine learning models demonstrated strong predictive accuracy, and kinase inhibitors were suggested as promising therapeutic targets based on pathway analysis.

This study found that patients with alopecia areata, particularly those with severe cases, exhibit significant systemic immune dysregulation, including altered cell communication networks and epigenetic remodeling in immune cells, suggesting potential pathways for therapeutic targeting.

This study identified a unique circulating microRNA signature associated with severe alopecia areata, distinguishing it from other inflammatory skin conditions and suggesting these miRNAs as non-invasive biomarkers for diagnosis and potential therapeutic targets.

This study found that in a large cohort of chronic kidney disease patients, nonprogression or regression of the disease was more common than progression or kidney failure, especially with advancing age.

In this descriptive retrospective study, researchers reported that low-dose oral minoxidil (0.25-5mg/day) for androgenic alopecia demonstrated a good safety profile, with 84.4% of 641 patients experiencing no adverse effects and only 1.4% discontinuing due to side effects that resolved with dose reduction or withdrawal.

This study found that topical clobetasol propionate cream was more effective than hydrocortisone cream in reducing hair loss surface area in children with patchy alopecia areata over 24 weeks, with no serious adverse effects.

This study demonstrates that a 3D-printed agarose microwell platform supports the growth of size-uniform, viable NSCLC cancer spheroids, and can effectively evaluate drug responses using limited tumor material from biopsies, particularly with EGFR tyrosine kinase inhibitors gefitinib and osimertinib.

This article discusses androgenetic alopecia, its progression, signs of hyperandrogenism, and impacts on quality of life, without presenting new clinical findings.

The woman's rare combination of diseases suggests an unknown factor may predispose individuals to multiple endocrine diseases.

This study found that the gut microbiota composition in patients with post-finasteride syndrome differs significantly from healthy controls, with reduced diversity and specific microbial changes, suggesting a potential diagnostic marker and therapeutic target.

This case report discusses the use of the Kono-S anastomosis technique in a patient with Crohn’s disease, suggesting it may offer benefits in reducing recurrence and preserving anastomosis dimensions, though further trials are needed to confirm its effectiveness.

In this study, the researchers highlighted the availability of new topical and systemic agents with varied mechanisms for treatment, emphasizing that the choice of agent should be tailored to individual needs and the options available in different countries.

This review highlights caffeine's diverse benefits in cosmetics and nutricosmetics, noting its antioxidant properties, ability to treat skin disorders like androgenic alopecia, and potential to enhance sunscreen effectiveness, though penetration into deeper skin layers remains challenging.

Healthcare professionals need better training and systems for drug interaction reporting, injectable vitamin B12 helps tingling, oral helps numbness, probiotics may help ulcerative colitis, and more research is needed on Post-Finasteride Syndrome.

This review provides a comprehensive overview of the mechanisms, efficacy, and adverse reactions of drugs commonly used for treating benign prostatic hyperplasia but reports no new clinical results.

In this study, the researchers observed that treatment with intralesional and topical corticosteroids, finasteride, and minoxidil may stop the progression of frontal fibrosing alopecia in postmenopausal and premenopausal women.

This study found that latanoprost may be effective for treating eyelash alopecia areata, achieving cosmetically acceptable regrowth in 45% of patients.

This study found that hairline measurements in white Spanish women differ from those previously reported for American women, which may be important for hair transplantation evaluations in alopecia cases.