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In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.

This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.

This review outlines how combining biomembrane-based nanostructures and microstructures with hydrogels can enhance strategies for chronic wound healing, by utilizing the unique properties of both to address metabolic disturbances and severe symptoms in wound care.

This review explores the different types of hydrogels used to repair diabetic ulcers, the mechanisms involved, and the limitations in developing these technologies for clinical use, but it reports no new clinical results.

This review discusses recent advancements in responsive-hydrogel dressings for diabetic wound healing, highlighting their design, responsiveness, and degradation behavior, and evaluating their potential advantages and limitations in clinical applications.

In this study, researchers developed a dexpanthenol-infused nanotechnological platform within hyaluronic acid hydrogels that promoted wound healing in mice by providing a protective barrier and significantly enhancing skin regeneration, including increased fibroblast activity and tissue remodeling.

This study found that encapsulating hADSCs-derived exosomes in PF-127 hydrogel improved wound healing in mice, suggesting a promising approach for enhancing skin repair.

This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.

This review explores how combining extracellular vesicles with hydrogels and utilizing 3D bioprinting technologies creates innovative composite systems for wound healing, offering advanced mechanical and biological support, while addressing challenges like degradation and regulatory issues in clinical applications.

This review details various components used in hydrogel composites for treating chronic diabetic ulcers and highlights potential future materials but reports no new empirical findings.

This review article highlights recent advancements in smart hydrogels as promising solutions for diabetic wound management, emphasizing their ability to respond to wound environments and deliver targeted therapies, while addressing limitations of traditional dressings.

This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.

In this study, hUCMSCs-Exo significantly accelerated wound healing in rat perianal fistulas with notable safety, potentially through the activation of the HIF-1α/TGF-β/Smad signaling pathway.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.

This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.

This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.

This study observed that exosomes derived from adipose-derived stem cells significantly enhanced bone marrow mesenchymal stem cell migration and osteogenesis, leading to improved bone regeneration in a rat model of calvarial defects.

This review highlights icariin’s potential to regulate macrophages in varying conditions, discussing its effects on macrophage polarization, metabolism, and disease mechanisms, and noting the development of delivery systems to enhance its therapeutic impact.

This meta-analysis found that ADSC-Exo therapy can enhance healing in both general and diabetic wounds by promoting neovascularization, improving epithelization and collagen fiber deposition, and reducing scar formation, suggesting significant potential for clinical and research applications.

In this review, the authors discuss the promising role of exosomes from various cell sources as potential cell-free therapies for diabetic foot ulcers, highlighting their therapeutic benefits in wound healing and the challenges faced in their clinical application.

This review discusses nanotechnology-based therapies for chronic wound healing and highlights their potential, but it reports no new clinical results.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.