14 citations
,
October 2011 This review discusses the clinical significance of L-Lysine in treating various conditions and reports mixed findings on its effectiveness against herpes simplex virus infections, with no new experimental results presented.
38 citations
,
January 2002 in “Biological & Pharmaceutical Bulletin” This study reported that the aqueous ethanol extract of Lygodii Spora demonstrated in vitro testosterone 5alpha-reductase inhibition and in vivo anti-androgenic activity, potentially due to oleic, linoleic, and palmitic acids.
1 citations
,
April 2006 in “International Journal of Oncology” In this study, lysocellin induced G1 phase arrest in human osteosarcoma cells, but diminished the cytotoxic efficacy of etoposide, while its derivative alopestatin may reduce etoposide-induced alopecia in a rat model.
23 citations
,
November 2021 in “Frontiers in Chemistry” This review discusses the catalytic mechanisms and potential applications of nanozymes in areas like tumor therapy and biosensing, but reports no new experimental findings.
8 citations
,
April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.
October 2021 in “Authorea (Authorea)” In this study, using tyrosine as a cross-linking agent for hair perming showed better initial results compared to commercial products, though efficiency decreased after washing without compromising hair strength.
133 citations
,
November 2018 in “Aging” This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.
January 2024 in “Authorea (Authorea)” This study found that laccase-assisted grafting of poly(tyrosine) onto wool materials improved shrinkage resistance and mechanical properties while causing minor decreases in crystallinity and thermal resistance, suggesting a potential "green" approach to enhance wool durability.
75 citations
,
March 2007 in “Journal of Biological Chemistry” This review discusses the complexities and uncertainties in the pathways and mechanisms for disulfide bond formation in multicellular organisms and reports no new experimental findings.
November 2025 in “ACS Nano” This study reported the development of a pH-responsive microreactor that effectively targets infections by eradicating over 99.9% of MRSA and reprogramming the immune response to promote healing, achieving complete infection clearance and tissue regeneration in a 7-day period.
22 citations
,
December 2020 in “mSphere” This study identified a fungal sulfotransferase enzyme, FgSULT1, from *Fusarium graminearum*, expanding the sulfotransferase superfamily and offering new biocatalytic methods for producing bioactive sulfates.
195 citations
,
February 2005 in “Journal of biological chemistry/The Journal of biological chemistry” This study shows that ZIP7 is a functional zinc transporter in mammalian cells, facilitating the movement of zinc from the Golgi apparatus to the cytoplasm.
August 2026 in “Scientific Reports” This study suggests that a Lentinula edodes extract can improve skin barrier function, hydration, and sebum regulation, possibly by modulating vitamin D pathways, in individuals with oily and acne-prone skin.
23 citations
,
February 2020 in “PLOS genetics” This study found that biallelic LSS mutations lead to congenital hypotrichosis and cataracts, with each tissue-specific loss of function observed in mouse models.
29 citations
,
August 2005 in “Biopolymers” In this study, researchers found that L-cysteine interacted electrostatically with anionic ions on the surface of keratin fibers in human hair, reducing the rate of disulfide bond disconnection at pH 9.0.
22 citations
,
February 2024 in “Heliyon” This review discusses the potential of fibrinolytic enzymes from various sources, especially fermented foods, for their therapeutic use in cardiovascular diseases and emphasizes the need for further research on those from non-Asian regions to optimize discovery and application.
1 citations
,
November 2011 in “British journal of pharmacology” This abstract provides a comprehensive overview of enzyme classification, function, and interaction with drugs, but does not present new research findings.
29 citations
,
June 2018 in “Scientific Reports” In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.
202 citations
,
June 2005 in “Aaps Pharmscitech” This review discusses the potential of lecithin organogels for improving topical drug delivery and presents no new experimental results; the authors highlight their stability and low skin irritancy as advantages.
66 citations
,
August 2007 in “Applied and environmental microbiology” This study engineered a bioluminescent yeast strain responsive to androgenic chemicals, demonstrating rapid and sensitive detection suitable for high-throughput screening and environmental monitoring.
2 citations
,
August 2019 in “International Journal of Applied Pharmaceutics” This study explored the use of SOD-loaded niosomes as carriers to enhance the delivery of superoxide dismutase into hair follicles on guinea pig skin, finding that niosomes improved SOD penetration and preservation compared to free SOD, suggesting their potential as effective delivery vehicles.
22 citations
,
November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that cathepsin L and transglutaminase 3 colocalize in the human hair bulb and nail matrix, suggesting their involvement in terminal differentiation within these epidermal appendages.
April 2026 in “Trends in biotechnology” This review explores the potential of nanozymes as artificial enzymes with diverse applications but highlights the need for more research into their mechanisms, safety, and scalability before they can be effectively translated into clinical use.
1 citations
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July 2025 in “Advanced Materials” This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.
9 citations
,
August 2007 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This study observed that amino acid uptake into wool follicles varies significantly, with cysteine showing the highest uptake rate, suggesting specialized transport systems that may influence wool growth.
5 citations
,
August 1983 in “PubMed” This study found that isozyme profiles in polyoma virus-induced tumors were consistent and distinctive for each tumor type, except for salivary and mammary tumors which shared a profile.
2 citations
,
June 2004 in “Journal of Molecular Histology”
January 2024 in “Biochemistry Research International” This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.
20 citations
,
March 2023 in “Drug Delivery and Translational Research” This study found that a lacticin 3147 solid lipid nanoparticle gel demonstrated potent and sustained antimicrobial activity against S. aureus, including MRSA, in ex vivo S. aureus-infected pig skin.
17 citations
,
August 2010 in “International Journal of Cosmetic Science” This study found that a cosmetic formula containing 2% Orthosiphon stamineus leaf extract significantly reduced skin oiliness and pore size, showing better results than a formula with 1% zinc gluconate.