April 2019 in “Journal of Investigative Dermatology” The study suggests that variability in platelet-derived growth factors in PRP is influenced by both patient-to-patient differences and the devices used for PRP preparation, contributing to inconsistent clinical outcomes in hair loss treatments.
August 2018 in “Journal of the American Academy of Dermatology” Patients often experience long-lasting changes to their hair after stem cell transplants.
July 2018 in “Elsevier eBooks” This review discusses novel treatments for androgenetic alopecia, including therapies like platelet-rich plasma and adipose-derived stem cells, and reports no new clinical results.
April 2018 in “D-Scholarship@Pitt (University of Pittsburgh)” This study found that keratin-75, discovered in enamel tissue, is secreted by ameloblasts using an unconventional pathway involving the ER-Golgi-Intermediate-Compartment and Golgi, differing from typical cytokeratin localization.
This chapter reviews the presence and roles of stem cells in various body systems, focusing on their lifelong function in animals and humans, and reports no new experimental findings.
April 2017 in “Journal of Investigative Dermatology” This study reports a new optimized protocol for isolating and labeling single cells from neonatal mouse skin, enabling high-quality single cell RNA sequencing for lineage-specific cell analysis.
April 2017 in “Journal of Investigative Dermatology” This study found that hair follicle matrix progenitors differentiate into various layers asynchronously, with early progenitors forming the companion layer and later progenitors generating the inner root sheath and hair shaft.
April 2017 in “Journal of Investigative Dermatology” This study identified that in mice, sweat gland development is directed by mesenchymal signals that suppress SHH-production, while in humans, this occurs through a BMP spike in embryonic development.
April 2017 in “Journal of Investigative Dermatology” This study found that down-regulation of sonic hedgehog gene expression is a critical early event in chemotherapy-induced tissue damage in hair and feather follicles.
April 2017 in “Journal of Investigative Dermatology” In this pilot study, researchers observed a correlation between clinical severity and histologic severity of lichen planopilaris, suggesting that an immunohistochemical scoring system could aid in grading disease activity.
January 2017 in “Elsevier eBooks” This chapter discusses charnolopharmacotherapeutics for various medical conditions and suggests antioxidant-loaded nanoparticles may improve treatment by enhancing central nervous system delivery and inducing charnolophagy.
April 2016 in “Journal of Investigative Dermatology” This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.
April 2016 in “Journal of Investigative Dermatology” This symposium reviewed various topics in stem cell research related to skin biology, including mechanisms of skin regeneration, tumorigenesis, and pathways influencing melanoma stem cell behavior, but it reported no new clinical results.
August 2015 in “Free Radical Biology and Medicine” Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.
August 2015 in “Free Radical Biology and Medicine” This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.
This study found considerable variation in hair shaft proteomic profiles among Caucasian, African-American, Kenyan, and Korean subjects, with individual and site-specific differences observed.
This study used proteomic profiling to reveal significant individual and site-specific differences in human hair shaft proteins, which may improve the differentiation of hair based on ethnic origin and individual identity.
May 2014 in “La Revue de médecine interne” This article reviews the specific cosmetology needs and practices related to black skin, identifying associated complications, and emphasizes the need for a robust cosmetovigilance policy but reports no new clinical findings.
September 2013 in “Science” In this study, researchers found that undergraduate research experiences improved students' research skills, research self-efficacy, and aspirations for research careers, with self-efficacy partially mediating the effect on career aspirations.
September 2013 in “Science” The document concludes that human astrocytes aid stroke recovery, research confidence affects student career aspirations, collagen affects cancer spread, a microRNA suppresses brain cancer growth, calmodulin regulates water channels, and small magnesium pieces deform differently.
September 2013 in “Science” Certain astrocytes can protect the brain and improve recovery after a stroke, and a hair loss drug might reduce cancer spread.
September 2013 in “Science” Human stem cells can aid stroke recovery, research experiences boost students' career aspirations, minoxidil may reduce cancer spread, a molecule can slow tumor growth, a protein affects water flow in cells, magnesium behaves differently at tiny scales, and a new method detects slow-moving objects.
September 2013 in “Science” This study found that single-crystal magnesium samples smaller than 100 nm exhibited increased plastic deformation due to greater activation of nonbasal planes as local flow stresses approached 2 GPa.
September 2013 in “Science” This article discusses the Doppler effect as illustrated by the sound of a passing police siren but presents no new research findings.
September 2013 in “Science” Transplanted human Olig2+ astroglia may help improve learning and memory after a stroke.
September 2013 in “Molecular Biology” This study found that Satura Rosta Balm exerts a cytotoxic effect under oxidative stress and may trigger regeneration through autophagic pathways, despite not promoting proliferation or stress resistance in human cells.
August 2013 in “Pharmacy Today” In a recent study of 15 women with self-perceived hair loss, Viviscal supplementation was associated with an increase in terminal hairs and subjective improvement in hair characteristics.
December 2012 in “Journal of Dermatological Science” This study found that activating Wnt/beta-catenin signaling in hair follicles is sufficient to induce adipocyte generation in the dermis, affecting both hair follicle stem cell activation and adipocyte differentiation.
Early balding may be a sign of future prostate problems.
Men with early balding may have a higher risk of prostate issues, and surgery for prostate cancer has a slight survival benefit over radiation.