February 2024 in “Research Square (Research Square)” In this study, researchers reported that both PRP and L-GF injections are effective in enhancing hair density and reducing recovery time post-transplantation in men with androgenetic alopecia, with L-GF showing slightly better but statistically insignificant results.
February 2021 in “Dermatologic Therapy” This study concluded that intralesional lyophilized growth factor injections are safe and improve trichoscopic hair parameters and clinical scores in patients with female pattern hair loss.
October 2021 in “QJM: An International Journal of Medicine” In this pilot study, treatment with lyophilized platelet derived growth factors showed improvement in women with androgenetic alopecia, suggesting it may be a promising new therapy.
May 2024 in “Archives of dermatological research” LGFs slightly improve hair transplant results more than PRP.
May 2023 in “Scientific Reports” This study found that Lepidium sativum seed extract showed potential in treating alopecia in rats by reducing 5(alpha)-dihydrotestosterone levels and improving hair length compared to minoxidil.
This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.
November 2021 in “International Journal for Research in Applied Science and Engineering Technology” This review discusses the various applications of lyophilized platelet-rich plasma in treating different diseases and reports no new clinical results.
8 citations
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February 2025 in “Frontiers in Medicine” This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.
January 2020 in “Majalah Kedokteran Gigi Indonesia” The researchers reported that freeze-dried collagen-activated platelet-rich plasma increased transforming growth factor-β1 levels compared to non freeze-dried PRP with collagen, suggesting a potential benefit for tissue regeneration.
April 2023 in “Egyptian journal of Immunology” This study found that human platelet lysate supported mesenchymal stem cell growth as effectively as fetal bovine serum, while fetal bovine serum was more effective for hepatocyte proliferation.
96 citations
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December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
28 citations
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September 2019 in “International Journal of Nanomedicine” This study found that minoxidil nanoparticles increased drug delivery to hair follicles and improved hair growth more effectively in mice than conventional minoxidil formulations.
24 citations
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January 2015 in “Evidence-based Complementary and Alternative Medicine” In this study, Polygonum multiflorum Radix promoted hair growth in mice, with oral administration being more effective, likely through FGF-7, while topical application favored SHH-related mechanisms.
22 citations
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February 2023 in “Heliyon” This study reports that a heparin-based sericin hydrogel encapsulating basic fibroblast growth factor significantly accelerated wound healing in mice by enhancing vascularization, re-epithelialization, and collagen deposition.
12 citations
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January 2021 in “Journal of Cutaneous and Aesthetic Surgery” This systematic review describes current findings on the use of recombinant epidermal growth factor (rhEGF) for skin aging and wound healing, emphasizing its potential benefits but highlighting the need for more controlled studies to optimize dosing and treatment protocols.
7 citations
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November 2022 in “Communications biology” This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
6 citations
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January 2016 in “Evidence-based Complementary and Alternative Medicine” In this study, fermented herbal extracts promoted hair growth and activated Wnt signaling more effectively than nonfermented extracts in mice, suggesting potential benefits for hair regrowth.
4 citations
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January 2017 in “PubMed” This study found that adding epidermal growth factor to mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats compared to stem cells alone.
5 citations
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January 2022 in “Molecular Medicine Reports” In this study, topical application of Korean maritime pine bark extract at 2% concentration significantly promoted hair growth in mice, suggesting its potential use for hair loss prevention or treatment.
July 2023 in “Research Square (Research Square)” In this study conducted on rabbits, conventional blood treated with 120% sodium citrate was observed to achieve the highest platelet recovery and enrichment coefficient, while altering sodium citrate concentrate affected levels of growth factors PDGF and TGF-β1 after plasma activation.
8 citations
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June 2019 in “Journal of Ginseng Research” This study found that a gintonin-enriched fraction from ginseng promoted hair growth in mice by stimulating dermal papilla cell proliferation and increasing hair follicles and weight.
3 citations
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December 2016 in “Blood” This study found PRP treatment significantly increased hair count and anagen hairs in male patients with androgenetic alopecia, but there was no correlation between therapeutic response and platelet or growth factor levels.
7 citations
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January 2024 in “Regenerative Biomaterials” This study developed a multifunctional core-shell fiber dressing that preserves platelet-rich plasma for 180 days, facilitating sustained growth factor release and improved wound healing.
February 2024 in “Asian Journal of Pharmaceutical and Clinical Research” This study found that human platelet lysate, prepared from expired platelet concentrate, maintained stable growth factor levels for up to six months and improved healing in second-degree burn wounds compared to standard silver sulfadiazine treatment at three weeks.
February 2023 in “Journal of Advanced Research” This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.
10 citations
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July 2019 in “Journal of Asia-Pacific Entomology” This study suggests that ultra-fine powders of steamed and lyophilized mature silkworms may have enhanced pharmacological effects compared to fine powders, possibly due to their smaller particle size.
August 2025 in “Bioactive Materials” In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.
May 2024 in “Journal of cosmetic dermatology” This study investigated the effects of heat-treated Limosilactobacillus fermentum LM1020 on hair growth and reported increased hair density, improved cellular activity, and beneficial scalp microbiota changes in patients with androgenetic alopecia over 24 weeks.
103 citations
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June 2018 in “International Journal of Molecular Sciences” This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.