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DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Stem cell self-renewal is complex and needs more research for full understanding.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Different types of stem cells and their environments are key to skin repair and maintenance.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Higher doses of cranial irradiation are linked to permanent hair loss.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

Hair loss linked to higher heart disease risk in both men and women.

PLD is an effective and safer alternative for treating breast cancer.

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.