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    Glossary LY294002

    chemical inhibitor of enzyme PI3K, affecting cell growth

    LY294002 is a chemical compound that inhibits a specific enzyme called PI3K (phosphoinositide 3-kinase). This enzyme is involved in various cellular processes, including cell growth, proliferation, and survival. By blocking PI3K, LY294002 can help researchers study the role of this pathway in diseases like cancer and potentially develop targeted therapies.

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    Research 30 of 85

    1. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase 2009 · 34 citations
    2. Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury The Kaohsiung Journal of Medical Sciences · 2020 · 6 citations
    3. Effect of Puerariae Radix Ethanol Extract on the Proliferation of Human Dermal Papilla Cells Journal of Physiology & Pathology in Korean Medicine · 2017 · 3 citations
    4. A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice Biological & Pharmaceutical Bulletin · 2005 · 3 citations
    5. Wheat Sprout Extract Stimulates Cell Proliferation via Phosphorylation of ERK and Akt in Human Dermal Papilla Cells 2017
    6. Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model Journal of Biomedical Nanotechnology · 2022
    7. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis Cell Stem Cell · 2016 · 106 citations
    8. Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways Archives of Dermatological Research · 2019 · 18 citations
    9. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    10. Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells <i>via</i> Anagen-Activating Signaling Pathways Biological & Pharmaceutical Bulletin · 2018 · 5 citations
    11. Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway Journal of Ovarian Research · 2025
    12. Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase Asian journal of Current Research in Clinical Cancer · 2022
    13. Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells Proceedings of the National Academy of Sciences of the United States of America · 2017 · 92 citations
    14. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway Life Sciences · 2019 · 28 citations
    15. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    16. Induction of versican by ascorbic acid 2-phosphate in dermal papilla cells Journal of Dermatological Science · 2006 · 22 citations
    17. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    18. Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway Journal of Applied Biomedicine · 2013 · 11 citations
    19. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    20. Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth 2019 · 7 citations
    21. 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1 Archives of Biochemistry and Biophysics · 2001 · 4 citations
    22. Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets Pharmaceutical Research · 2025 · 2 citations
    23. Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection Nature Communications · 2025
    24. Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli 2025
    25. 毛乳頭細胞と毛包上皮細胞間の細胞内・細胞外情報伝達 Institutional Repositories DataBase (IRDB) · 2022
    26. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations
    27. TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs Stem Cell Research & Therapy · 2025
    28. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    29. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    30. Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway BMC Complementary and Alternative Medicine · 2019 · 10 citations