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The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.

Urologic diseases and treatments in older men can negatively affect fertility, and doctors should talk to patients about this.

The guidelines help doctors diagnose and treat hormone-related disorders in women.

A postmenopausal woman's excess male hormone symptoms improved after her ovaries were removed.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

The document concludes that hair loss in women can be treated with topical treatments or hormone therapy depending on the cause.

Oestrogens are key for bone growth during puberty in both boys and girls.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Skin symptoms can indicate endocrine disorders and have various treatments.

The testes produce important hormones like testosterone and others that play key roles in male body functions.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

The new oral testosterone pill normalized testosterone levels and lowered SHBG in men with low testosterone.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

Pregnant women with PCOS have higher levels of Neurokinin B in the placenta, especially with female babies.

Centratherum anthelminticum seed extract effectively treats Polycystic Ovary Syndrome in rats.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.

A woman with anorexia and Cushing's syndrome improved after tumor removal, highlighting the need to consider hormonal issues in psychiatric conditions.