December 2022 in “Türk biyokimya dergisi” The conclusions are: fecal short-chain fatty acids may help prevent cancer, fiber intake can reduce obesity, weight loss is hard for obese people, low BMI cancer patients are more prone to chemotherapy side effects, intermittent fasting benefits gut health, cherry laurel has health benefits in rats, certain gene variations can increase stress in hair loss patients, fecal acids can affect blood sugar levels, cold agglutinin can affect blood test results in autoimmune patients, and people with Crohn's disease have higher levels of a certain chemical in their blood.
October 2022 in “Biomedicines” The review investigates the transgenerational effects of finasteride-induced androgen imbalance on endoplasmic reticulum (ER) stress, oxidative stress, and liver disorders. It was found that finasteride treatment in male rats led to significant metabolic and cellular stress in their offspring, including hyperglycemia and increased hepatic glycogen accumulation. The study highlights the role of androgen receptors in regulating ER stress and the unfolded protein response (UPR) in the liver, suggesting that these mechanisms could be potential therapeutic targets for liver diseases. The findings emphasize the need for further research into how finasteride and similar drugs may induce hereditary changes affecting offspring health.
46 citations,
January 2020 in “Research” Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.
10 citations,
February 2021 in “American Journal Of Pathology” Integrin β1 is crucial for liver structure and function, preventing fibrosis.
9 citations,
November 2020 in “The FASEB journal” Intermediate filaments are crucial for cell differentiation and stem cell function.
7 citations,
July 2013 in “InTech eBooks” Oral lichen planus is a chronic disease causing mouth discomfort and sometimes needs immunosuppressive treatment.
1 citations,
November 2022 in “Animals” The research found specific genes and pathways that control fur development and color in young American minks.
May 2020 in “Authorea (Authorea)” Olfactory receptors found outside the nose may offer new treatments for diseases like cancer and help in wound healing and hair growth.
131 citations,
April 2018 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
96 citations,
September 2021 in “International Journal of Molecular Sciences” Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
81 citations,
February 2016 in “Veterinary pathology” Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
56 citations,
January 2008 in “Molecular and cellular endocrinology” Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.
53 citations,
January 2013 in “Journal of toxicologic pathology” The project created a standardized system for classifying skin lesions in lab rats and mice.
13 citations,
November 2017 in “Journal of Cellular and Molecular Medicine” The workshop discussed the role of a protein called calreticulin in health and disease, its potential as a treatment target, and its possible use as a disease marker.
9 citations,
February 2022 in “Biomolecules” Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.
6 citations,
April 2023 in “Biomaterials Research” Special gels help heal diabetic foot sores and reduce the risk of amputation or death.
5 citations,
June 2022 in “Frontiers in Endocrinology” Research from 2011 to 2020 shows androgen receptors could be key for prognosis and treatment in certain breast cancers.
4 citations,
December 2022 in “International Journal of Molecular Sciences” Zinc is crucial for skin health and treating various skin disorders.
3 citations,
June 2023 in “Molecules/Molecules online/Molecules annual” Cepharanthine has many medicinal uses but needs improvement for better effectiveness.
2 citations,
January 2023 in “Bioscience Reports” Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.
2 citations,
November 2022 in “Veterinary sciences” The interdigital gland of Vembur sheep shows sex-based differences in size and chemical makeup, possibly affecting communication and disease protection.
2 citations,
January 2021 in “Asian pacific Journal of Tropical Biomedicine” The study concluded that Origanum vulgare L. leaf extract effectively alleviated oxidative stress in the liver and kidney of mice induced by finasteride. The extract, particularly at doses of 200 and 400 mg/kg/day, significantly improved liver and kidney function, reduced inflammatory cytokines, increased antioxidant status, and decreased oxidative stress markers. Histopathological analysis confirmed these protective effects, indicating that Origanum vulgare extract could be a beneficial supplement for reducing oxidative stress and mitigating finasteride-induced hepatic and renal damage.
1 citations,
June 2022 in “Pharmaceutics” The study investigates the intestinal absorption and biopharmaceutical characterization of minoxidil, focusing on paracellular transport using in-silico, in-vitro, and in-vivo methods. It finds that minoxidil's permeability is pH-independent and significantly influenced by tight junction modifiers, with quercetin decreasing and sodium decanoate increasing permeability. Approximately 15% of minoxidil is absorbed paracellularly, primarily in the proximal intestine. Due to the variability introduced by paracellular transport, minoxidil is unsuitable as a Biopharmaceutics Classification System (BCS) reference drug for low/high permeability classification.
March 2024 in “Veterinary sciences” Geriatric Julia Creek dunnarts often suffer from reproductive and skin diseases, impacting conservation efforts.
January 2022 in “IntechOpen eBooks” Some lesser-known causes of PCOS include autoimmune issues, genetic mutations, and changes in the body's microbiome.
11 citations,
June 2005 in “Stem Cells and Development” Intestinal stem cells can help repair skin damage from radiation.
6 citations,
July 2013 in “Molecular Imaging” The technique allowed noninvasive tracking of hair stem cell survival and growth, showing potential for hair loss research.
25 citations,
November 2017 in “Molecular Medicine Reports” PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.
56 citations,
May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
113 citations,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.