8 citations
,
June 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found that subclinical hypothyroidism had minimal impact on the metabolic and hormonal profiles of women with polycystic ovary syndrome.
182 citations
,
August 2016 in “Development” This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.
160 citations
,
January 2017 in “Development” This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.
139 citations
,
August 2018 in “Development” This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.
91 citations
,
August 2014 in “Development” This review discusses how circadian clocks may influence diverse physiological functions beyond their established role in daily timekeeping, but it reports no new experimental findings.
60 citations
,
November 2013 in “Development” This study found that the creation of hair follicle lumens in mice is driven by the outward migration of keratin 79-positive cells, suggesting a novel mechanism for generating hollow cores in hair follicles.
55 citations
,
September 2014 in “Development” In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.
11 citations
,
June 2017 in “Journal of cell science” In this study, researchers found that AGD1 is crucial for membrane recruitment during root hair development in Arabidopsis thaliana, with its pleckstrin homology domain essential for targeting specific plasma membrane regions.
6 citations
,
October 2022 in “Journal of cell science” This study re-analyzed single-cell RNAseq data from human and mouse skin, confirming and refining insights into keratin gene regulation during keratinocyte differentiation in epithelial tissues.
4 citations
,
May 2019 in “Biology open” This study found that while testosterone administration reduced myocardial damage in gonadectomized rats after ischemia/reperfusion injury, Finasteride led to greater improvements, whereas 4-hydroxyandrostenedione worsened outcomes.
4 citations
,
March 2017 in “Development” This study found that specialized nipple epidermis in mice is maintained by the repression of TGFβ signaling through estrogen, which highlights the role of hormonal regulation in epidermal maintenance.
2 citations
,
June 2023 in “Journal of cell science” In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.
96 citations
,
October 1981 in “Drugs” Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.
41 citations
,
September 1991 in “Medical hypotheses” This article reviews the potential role of prolactin as a neuroendocrine modulator in skin biology and pathology, discussing its relevance for conditions such as psoriasis and hair growth, but reports no new clinical findings.
19 citations
,
March 1990 in “Journal of Cardiovascular Pharmacology” Minoxidil affects rat fluid dynamics, altering pressure and circulation, improving blood flow and hair growth.
12 citations
,
September 2003 in “Current paediatrics” This review discusses topical and oral treatments for acne in children and provides guidance on tailoring these treatments according to acne severity, but it reports no new clinical results.
September 2003 in “Current Paediatrics” This article outlines how pediatric hair problems present and how they can be assessed, without reporting new research results.
2295 citations
,
August 2012 in “The international journal of transgenderism/International journal of transgenderism” This publication reviews the World Professional Association for Transgender Health's Standards of Care for supporting transgender and gender nonconforming people, with adjustments needed for diverse global contexts and no new clinical results.
759 citations
,
February 2009 in “Current Biology” This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
238 citations
,
March 2013 in “Development” This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.
211 citations
,
April 2013 in “Development” In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.
207 citations
,
March 2012 in “Development” In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.
165 citations
,
January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
134 citations
,
January 2011 in “Development” This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.
119 citations
,
October 1992 in “Fundamental & Clinical Pharmacology” This review discusses the pharmacological properties and therapeutic potential of K+ channel opening compounds, noting their prospective use in treating cardiovascular and respiratory conditions, but reports no new results.
97 citations
,
March 2009 in “Dermato-endocrinology” This review explores the role of hormones in pilosebaceous units and associated skin disorders, focusing on androgen action, without presenting new clinical findings.
82 citations
,
March 2012 in “Development” This study found that deleting the miRNA processing enzymes Drosha and Dicer from mouse skin epithelial cells disrupted normal hair follicle development and maintenance, leading to follicular degradation and stem cell loss during the growth phase.
72 citations
,
June 2001 in “Journal of Investigative Dermatology” This study suggests that S100A4 and S100A6 proteins may play key roles in activating stem cells for hair follicle regeneration in mice.
70 citations
,
June 1993 in “Biochemistry” This study found that the binding of finasteride to the enzyme 5a-reductase occurs at a slower rate than previously assumed, complicating the estimation of its real inhibitory constant.
66 citations
,
July 2015 in “Organogenesis” This review summarizes recent findings on how Wnt signaling proteins play crucial roles in the cutaneous wound healing process but reports no new clinical results.