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This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.

The enzyme PA-PLA1α is important for proper hair follicle development.

This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.

This study found that hinokitiol effectively suppressed TNF-α production in activated macrophage-like cells, suggesting it may help alleviate hair loss by mitigating factors that promote follicular apoptosis.

This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.

This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.

This study found that postmenopausal women with lichen planopilaris showed a high prevalence of androgen excess, while women with frontal fibrosing alopecia were often associated with androgen deficiency.

This review discusses the role of LPA(3) in embryo implantation and its genetic connection with prostaglandin signaling, but reports no new clinical results.

This study demonstrated that a device combining hyaluronic acid-based dissolving microneedles and lipid polymer hybrid nanoparticles effectively delivered miR-218 to promote hair growth in a shaved mouse model, outperforming topical smear treatment without safety concerns.

This study identified specific genetic variants as the cause of visual impairment and non-syndromic alopecia in two brothers, reinforcing the link between PDE6H variants and achromatopsia and LPAR6 variants and alopecia.

In this study, patients with androgenetic alopecia showed no difference in insulin resistance or prevalence of metabolic syndrome but had higher cardiovascular risk due to increased inflammatory markers and lipoprotein(a) levels.

This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.

In this study, deletion of ROBO4 in mice ameliorated hair loss caused by elevated PAF levels, suggesting potential interplay with VLDLR-related pathways.

This review discusses lipid-polymer hybrid nanoparticles for dermatological applications, outlining their structural and formulation advancements, but reports no new clinical results and calls for further research on their therapeutic potential.

This letter discusses three plasmacytoid dendritic cell-related parameters that may help differentiate lupus alopecia from lichen planopilaris, but it reports no new study results.

This study found that L-glutamine supplementation in Hanwoo steers under heat stress did not affect growth performance or muscle and adipose tissue gene expression but was associated with increased immune cells and reduced HSP90 expression.

Lichen planus pigmentosus and fibrosing frontal alopecia in Colombia are likely different stages of the same disease.

This study used cryoelectron microscopy to unveil the structure of LPA-bound human LPAR6, revealing unique ligand binding and recognition modes distinct from LPAR1, which may aid in designing targeted compounds for hair loss and cancer.

This study found that Ishige sinicola ethanol extract and its butanol fraction can protect against lipopolysaccharide-induced muscle atrophy in C2C12 myotubes through antioxidant and anti-inflammatory activities.

In this study involving 30 Kazakh women with systemic lupus erythematosus, the researchers found a strong correlation between disease activity (SELENA-SLEDAI scores) and organ damage (SLICC/ACR scores), which depended on disease duration and reliably reflected cumulative disease activity.

This case study reports clinical improvement and complete ulcer resolution in a 29-year-old woman with ANA-negative SLE treated for segmental hyalinizing vasculitis and valvular heart disease.

In this case report, a 19-year-old woman with systemic lupus erythematosus experienced significant improvement in neuropsychiatric symptoms, including psychosis and seizures, following treatment with high-dose corticosteroids, immunosuppressants, and antidepressants.

This case report highlights that Tjalma Syndrome may present as a main symptom of systemic lupus erythematosus and should be considered in patients with ascites, pleural effusions, and elevated CA-125 levels.

This study found significant correlations between scalp and nail involvement and laboratory findings in Korean patients with chronic cutaneous lupus erythematosus, highlighting their importance for diagnosis and management.

This study reviewed cases of Graham–Little-Piccardi–Lassueur syndrome and found that topical treatments were generally ineffective, while systemic therapies like prednisone, hydroxychloroquine, and isotretinoin led to partial hair regrowth and disease stabilization, highlighting the importance of early diagnosis and systemic therapy to improve outcomes.

This study used atomic force microscopy to identify significant morphological differences in hair from patients with lichen planopilaris compared to healthy controls, noting more scratches, uneven edges, and pitted scales in affected hair, which may aid future research on the condition.

This study found that the oral IRAK4-inhibitors BAY 1834845 and BAY 1830839 reduced skin inflammation and systemic inflammatory responses in healthy volunteers, showing similar pharmacodynamic effects to prednisolone when challenged with topical imiquimod and intravenous LPS.

This chapter provides dermatology trainees with insights on managing lichen planopilaris, emphasizing treating active disease to prevent further hair loss and recommending a tapered course of oral steroids for disease stabilization.

This study found that in women with PCOS, lipid-induced NFκB activation is independent of obesity and exhibited evidence of LPS tolerance in combination with obesity and hyperandrogenism.

In this study, repeated pregnancies in a murine model of systemic lupus erythematosus altered skin inflammation and cytokine expression but worsened kidney function and survival compared to controls.