research Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research
New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
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30 / 1000+ results research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-Alpha Production in LPS-Activated Macrophages via Suppression of NF-Kappa B
Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.
research Autotaxin-LPA Signaling Contributes to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism
Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.
research Prevalence of Hormonal and Endocrine Dysfunction in Patients with Lichen Planopilaris: A Retrospective Data Analysis of 168 Patients
Lichen planopilaris (LPP) is linked to androgen excess, while frontal fibrosing alopecia (FFA) is linked to androgen deficiency.
research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid
LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.
research A Lipid–Polymer Hybrid Nanoparticle-Loaded Dissolving Microneedle Patch for Promoting Hair Regrowth by Transdermal miR-218 Delivery
The microneedle patch effectively promotes hair regrowth by delivering miR-218.
research Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan
Genetic variants in PDE6H and LPAR6 cause vision impairment and hair loss in two Pakistani brothers.
research Inflammatory Markers and Lp(a) Levels as Cardiovascular Risk Factors in Androgenetic Alopecia
AGA patients have higher heart disease risk.
research ROBO4 Deletion Ameliorates PAF-Mediated Skin Inflammation by Regulating the mRNA Translation Efficiency of LPCAT1/LPCAT2 and the Expression of PAF Receptor
Removing the ROBO4 gene in mice reduces skin inflammation and hair loss by affecting certain inflammation pathways and gene expression.
research Reply to ‘CD123 Immunohistochemistry for Plasmacytoid Dendritic Cells Is Useful in the Diagnosis of Scarring Alopecia’: Three PDC-Related Parameters Are Useful in Differentiating Lupus Alopecia from LPP
Three characteristics of plasmacytoid dendritic cells help tell apart lupus-related hair loss from LPP.
research Lichen Planus Pigmentosus and Lichen Planus Pigmentosus: 35 Cases in Armenia, Colombia
Lichen planus pigmentosus and fibrosing frontal alopecia in Colombia are likely different stages of the same disease.
research The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions
Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.
research LP-161 Tjalma Syndrome (Pseudo-Pseudo Meigs Syndrome): Polyserositis With Increased CA-125 in Patients With Systemic Lupus Erythematosus
Tjalma Syndrome is a rare condition in people with lupus, causing fluid buildup and high CA-125 levels, but not due to tumors.
research The Involvement of Scalp and Nails in Cutaneous Lupus Erythematosus Patients: A Retrospective Study
Many patients with cutaneous lupus erythematosus experience hair loss and nail problems, which are important for diagnosis and treatment.
research Studying the Disease Activity and the Degree of Internal Organ Damage in Systemic Lupus Erythematosus Patients in the Kazakh Population
Higher disease activity in systemic lupus erythematosus is strongly linked to more internal organ damage.
research ANA-Negative Lupus Presenting with Segmental Hyalinizing Vasculitis and Valvular Heart Disease – A Rare Case Report
Early recognition and aggressive treatment can significantly improve rare ANA-negative lupus with heart and skin issues.
research Psychosis as an Early Manifestation of Neuropsychiatric Systemic Lupus Erythematosus – A Case Report
Psychosis can be an early sign of neuropsychiatric lupus, treatable with tailored medication.
research Evaluation of Hair Surface Structure and Morphology of Patients with Lichen Planopilaris by Atomic Force Microscopy
AFM can help diagnose lichen planopilaris by identifying specific hair structure changes.
research An Innovative Phase 1b Trial Demonstrating Proof-of-Pharmacology for Two Novel IRAK4-Inhibitors Using a Local and Systemic Driven Immune Response
Two new IRAK4-inhibitors effectively reduced skin inflammation and immune response markers in healthy volunteers.
research Hallmark Evidence of Lipopolysaccharide Tolerance in Obese Women with Polycystic Ovary Syndrome: LPS-Induced NFkB Suppression in Mononuclear Cells Linked to Hyperandrogenism
High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.
research TSPO Ligand Etifoxine Attenuates LPS-Induced Cognitive Dysfunction in Mice
Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.
research Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San
The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.
research Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study
The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.
research Lysophospholipid Mediators in Health and Disease
Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways
LPA3 signaling in the uterus is crucial for placental formation and fetal development.
research Lichen Planopilaris in the Androgenetic Alopecia Area: A Pitfall for Hair Transplantation
Misdiagnosis of LPP in AGA patients can cause hair transplant issues.
research A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia
New LPP subtype affects vellus hairs, mimics AGA, and needs biopsy for diagnosis.
research Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present?
Hair transplants for male baldness can show inflammation and fibrosis, but more research is needed to confirm LPP presence.
research Therapeutic Updates on Lichen Planopilaris and Frontal Fibrosing Alopecia: A Systematic Review
Antimalarial agents are effective for LPP, and intralesional steroids are effective for FFA.
research Immunofluorescent Findings and Clinical Overlap in Two Cases of Follicular Lichen Planus
GLPLS and LPP are variants of lichen planus.