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Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Hormonal male contraception is effective and could be market-ready, but more research is needed to ensure safety for all ethnic groups.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Early-onset male hair loss is linked to metabolic syndrome, suggesting a need for heart health monitoring and lifestyle changes.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Recognizing and managing central sensitization and stress is crucial for treating chronic pain.

Bariatric surgery improves ovulation rates in women with PCOS and obesity better than medical therapy.

The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.

Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

Many men misuse oral contraceptive pills for things like hair growth and muscle gain.

JAK-inhibitors for alopecia areata are generally safe with mostly mild side effects and a low rate of treatment withdrawal.

Women with PCOS have thicker parafoveal areas in their retinas, but their macular blood vessel density is normal.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.

Testosterone with finasteride improved muscle and bone health in men with spinal cord injury.

Mitochondrial dysfunction links metabolic syndrome and inflammatory skin diseases, suggesting targeted therapies and lifestyle changes.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

Certain gene variations in PITX2 are linked to a higher risk of male pattern baldness in Indians.

New treatments for alopecia areata show promise, but more research is needed to confirm their effectiveness.

The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.

The hemp extract significantly increased hair regrowth in both men and women without any side effects.

Povidone-iodine nail solution effectively treats nail infections caused by chemotherapy.

Laser treatment is safe and can effectively treat toenail fungus, especially when combined with other treatments if no improvement is seen after about a year.

Melatonin improved mental health and metabolism in women with PCOS.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Psoriasis is linked to a higher risk of autoimmune diseases and other health conditions.

People with psoriasis have more health problems, including autoimmune diseases, than those without it.