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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Finasteride and flutamide effectively reduce hirsutism in PCOS women, with flutamide also lowering hormone levels.

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Testosterone helps human pancreatic cells increase insulin release.

Diagnosing PCOS in teenage girls is tricky and requires careful evaluation and management.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Researchers found that certain RNA circles in the brain are linked to disease risk, but their exact role in disease is still unknown.

Self-monitoring blood pressure in pregnant women didn't improve outcomes, diabetes drugs may increase gallbladder disease risk, a new drug helps severe hair loss, a plant-based COVID-19 vaccine is 69.5% effective, and new anticoagulants are safer for diabetics with heart rhythm issues than warfarin.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Acne in dark skin is influenced by environmental factors and can lead to hyperpigmentation, with various treatment options available.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Diet changes can help reduce acne by limiting certain hormones.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Wheat straw is valuable for its health benefits and various industrial uses.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

Men are increasingly seeking quick-result cosmetic treatments for their thicker, oilier skin and hair loss issues.

Millets may help reduce chemotherapy side effects like nausea, fatigue, and hair loss.

Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.

Pine bark extract helps mice grow hair by reducing inflammation and boosting growth factors.

Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

African plants can treat hair issues and may help with diabetes.

A pregnant woman with Werner's syndrome died during childbirth, but her baby survived and did not have the syndrome.

GLP-1 receptor agonists help with weight loss but need to be combined with other treatments for best results.