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Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Capecitabine is as effective as intravenous treatments with fewer side effects, but requires careful management of Hand-foot syndrome and patient education.

Tacrolimus is effective for various skin conditions with fewer side effects than cyclosporine.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Alefacept showed some effectiveness for alopecia areata but needs more research.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Certain medications and maintaining adequate iron levels can help manage women's hair loss.

Allergic reactions to blood thinners are rare but can be serious, requiring careful management and alternative treatments.

Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

Two transplant patients on cyclosporine unexpectedly developed hair loss.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Spironolactone is effective and safe for treating acne with minimal side effects.

Birth control pills can help manage acne, but dermatologists should know their skin-related side effects, especially when prescribing drugs that can harm unborn babies.

Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Valproic acid increases the risk of hair loss more than other drugs, especially in migraine patients, and lamotrigine may be a safer alternative.

Oral isotretinoin for severe acne can change hormone levels but does not significantly affect ovarian function.

Multimodal primary treatment improves survival in premenopausal breast cancer patients and is also beneficial for postmenopausal women.

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

The document concludes that DAB389-IL2 is promising for treating refractory cutaneous T-cell lymphoma, but more research is needed on its effectiveness and side effect management.

The conclusion is that more research is needed to better understand and treat adult acne, and that patient education and simple treatment plans are important for better results.

Hormonal therapies, like flutamide and cyproterone acetate, are safe and effective for treating adult women's acne, especially those with hormone imbalance or resistant acne.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.