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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The 308-nm excimer laser is a promising treatment for vitiligo with varying success and mild side effects.

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

The flap assay grows the most natural hair but takes the longest, the chamber assay is hard work but gives dense, normal hair, and the patch assay is quick but creates poorly oriented hair with some issues.

Minoxidil was first made for high blood pressure, but it was later found to help hair growth.

Taking L-tryptophan supplements might cause a condition similar to scleroderma in some people, which can get better after stopping the supplement and starting corticosteroid therapy.

Genetic factors alone might not cause pemphigus vulgaris; other factors like birth complications and puberty may trigger it.

The study concluded that testing hormone levels after stimulation is not reliable for identifying carriers of 21-hydroxylase deficiency; genetic testing is necessary.

Apple polyphenols, especially from unripe apples, can help prevent cells from turning into fat cells.

Chinese patients with systemic lupus erythematosus commonly experience oral ulcers, arthritis, alopecia, skin rash, and nephritis.

New treatments for lupus show promise, but more research is needed, especially for children.

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

The document concludes that fexofenadine reduces inflammation in chronic hives, cholestyramine helps half of pregnant women with itchy rashes, and relaxing incisions are a good alternative in facial surgery for the elderly.

Early diagnosis, intensive therapy, and careful follow-up are crucial for managing overlapping TTP and SLE.

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

The document concludes that various skin conditions have specific treatments, ranging from antihistamines for urticaria to surgery and medication for tumors and chronic skin diseases.

CD4+ skin cells may be precursors to basal cell carcinoma.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

The document explains various skin conditions and their treatments.

UVB is good for a skin condition in Asian kids, a lotion works for head lice, a drug helps with a skin blistering disorder, a foam reduces itchiness in skin inflammation, birthmarks can be more widespread, and criteria for a neurocutaneous disorder were agreed upon.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.