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Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.

Macrophage activation syndrome can be a deadly first sign of systemic lupus erythematosus.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Absence of skin rash and low complement C3 levels increase the risk of lupus nephritis.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

A zinc-deficient diet stunted growth and affected organs in mice, with C57BL/6J mice showing more severe symptoms.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.

SLE and DM can coexist but are rare and need careful evaluation.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.

Iron deficiency might contribute to hair loss in women.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

A girl with hereditary chorea, likely Huntington's disease, had her condition worsened by lupus.

A woman with undifferentiated connective tissue disease was diagnosed with renal amyloidosis and carpal tunnel syndrome.

Pregnancy can cause skin changes and conditions that need correct diagnosis and treatment for the health of the mother and baby.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

Ancient hair can preserve hormones, revealing health and fertility insights.

A woman with lupus and severe nerve damage improved with specific treatments.

Older adults diagnosed with lupus show less severe symptoms but have a lower survival rate, often due to age-related factors.

The man was diagnosed with stage III multiple myeloma and treated to improve kidney function.

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.