Search

for
Search:

Glossary Lovastatin

medication that lowers cholesterol by inhibiting liver enzyme production

Lovastatin, also known by brand names such as Mevacor, is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins, which work by inhibiting an enzyme involved in the production of cholesterol in the liver, thereby reducing the risk of cardiovascular disease.

Sort by

Research

30 / 99 results

research The effects of lovastatin on conventional medical treatment of lower urinary tract symptoms with finasteride

24 citations , October 2008 in “International Braz J Urol”

In this study, short-term treatment with lovastatin showed no effect on symptom severity, prostate volume, or PSA levels in men with prostatic enlargement from presumed benign prostatic hyperplasia.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

research A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

4 citations , May 2021 in “Biomedicines”

This review explores the potential role of caveolin-1 in cicatricial alopecia, particularly frontal fibrosing alopecia, and discusses possibilities for targeted therapies without providing new research results.

research Scalp Porokeratosis: Dermoscopy's Key Role in Unmasking a Hidden Condition

October 2024 in “Dermatology Practical & Conceptual”

The researchers recommend considering porokeratosis as a possible diagnosis for scalp lesions since accurate identification is crucial for management and new treatments like topical cholesterol/lovastatin show promising potential for treating porokeratosis.

research The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

November 2023 in “Brain Sciences”

This study investigated medications potentially linked to male-factor infertility using the FDA Adverse Event Reporting System and found that finasteride, testosterone, valproate, and other drugs showed significant disproportionate reporting of infertility cases, highlighting a potential under-reporting issue to regulatory bodies.

research 026 Targeting pathogenic MICA-NKG2D interactions by statins: A novel adjunct treatment strategy for alopecia areata management?

November 2022 in “Journal of Investigative Dermatology”

This pilot study suggests that lovastatin may counteract stress-induced MICA expression in hair follicles and enhance MICA shedding, potentially offering a complementary approach for alopecia areata treatment.

research Diffuse hair loss in Addison disease: A reason for X-linked adrenoleukodystrophy screening

3 citations , April 2012 in “Journal of the American Academy of Dermatology”

Men with Addison disease should be screened for X-linked adrenoleukodystrophy if they have hair loss.

research Volatile signalling by sesquiterpenes from ectomycorrhizal fungi reprogrammes root architecture

193 citations , February 2015 in “Nature Communications”

Fungi-produced compounds can change plant root growth.

research Lipid levels in patients with lichen planus: a case-control study

45 citations , February 2011 in “Journal of the European Academy of Dermatology and Venereology”

This study found that patients with lichen planus had significantly higher levels of triglycerides, total cholesterol, and LDL-C, and lower HDL-C compared to healthy controls, suggesting an association with dyslipidaemia.

research Case number 19th of perforating necrobiosis lipoidica worldwide

2 citations , January 2018

This article reports the first case of perforating necrobiosis lipoidica in Colombia and the 19th case worldwide in diabetic patients.

research Hiperandrogenismo tras la menopausia

January 2013 in “Revista Clínica Española”

This review discusses female hyperandrogenism, detailing diagnostic criteria and treatment options without reporting new study results; it emphasizes improving health and quality of life for affected women.

research A Comprehensive Review on Metabolic Syndrome

1341 citations , January 2014 in “Cardiology Research and Practice”

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

research National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2

391 citations , September 2015 in “Journal of Clinical Lipidology”

This document extends previous recommendations by the National Lipid Association for managing dyslipidemia, focusing on lifestyle therapies, special patient groups, and strategies to enhance adherence and patient outcomes.

research Hormesis and medicine

127 citations , June 2008 in “British Journal of Clinical Pharmacology”

This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.

research Tinea Capitis: An Overview with Emphasis on Management

89 citations , May 1999 in “Pediatric Dermatology”

This article reviews the treatment options for tinea capitis, suggesting that itraconazole, terbinafine, and fluconazole are effective and safe alternatives to griseofulvin but reports no new clinical results.

research Repurposing of approved cardiovascular drugs

73 citations , September 2016 in “Journal of Translational Medicine”

This review discusses the drug repurposing of cardiovascular medications like aspirin and statins for new uses, including potential anti-tumor effects, noting promising experimental outcomes but less conclusive clinical trials, particularly in the field of cancer treatment.

research Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery

47 citations , April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.

research Steroid plant hormones: Effects outside plant kingdom

46 citations , September 2014 in “Steroids”

This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.

research Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications

39 citations , April 2020 in “IntechOpen eBooks”

The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

39 citations , November 2015 in “Nanomedicine”

This study found that the developed Finasteride-loaded SMEDDS improved the relative bioavailability of the drug compared to a commercial tablet, offering a promising oral delivery system for glucosteroid analogs.

research New approaches to the treatment of osteoporosis

28 citations , August 2000 in “Current Opinion in Chemical Biology”

This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.

research The placebo effect and randomized trials: analysis of conventional medicine

26 citations , February 2002 in “Urologic clinics of North America”

This review examines the placebo response in conditions such as allergies and weight loss, highlighting its significance in both conventional and alternative medicine randomized trials, without reporting any new results.

research Adverse health effects of androgen use

25 citations , June 2017 in “Molecular and Cellular Endocrinology”

This review discusses the negative effects of anabolic androgenic steroids on various organ systems in men and reports no new results, highlighting the need for physician awareness.

research Adverse Dermatologic Effects of Cardiovascular Drug Therapy: Part III

15 citations , November 2002 in “Cardiology in Review”

This review discusses various adverse skin reactions linked to cardiovascular medications and reports no new clinical results, highlighting the need for vigilance when prescribing these drugs.

research Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

13 citations , March 2019 in “Pharmacology Research & Perspectives”

This study analyzed CADR reports in Singapore, finding nonsteroidal anti-inflammatory drugs, antibiotics, and iohexol frequently associated with serious skin reactions like rash and angioedema, with trends varying by demographics.

research A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia

13 citations , March 2017 in “Genomics”

This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.

research Ovary and uterus related adverse events associated with statin use: an analysis of the FDA Adverse Event Reporting System

11 citations , July 2020 in “Scientific Reports”

This study suggests that statins may be linked to various ovary and uterus related adverse events, highlighting the need for monitoring in clinical practice.

research Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer

11 citations , April 2013 in “Journal of Agricultural and Food Chemistry”

This study found that Monascus cursory extraction reduced baldness, prostate hyperplasia, and tumor incidence in animal models of androgen-related diseases, suggesting it may be a promising new therapeutic candidate.

research Cardiodermatology: the heart of the connection between the skin and cardiovascular disease

10 citations , November 2024 in “Nature Reviews Cardiology”

Skin conditions can signal heart issues, highlighting the need for integrated care.

research Progestogens in menopausal hormone therapy

10 citations , January 2015 in “Przeglad Menopauzalny”

This review discusses the effects and selection criteria of different progestogens in various treatments but reports no direct clinical comparisons of their metabolic effects.