182 citations,
May 2003 in “Development” The study demonstrated that Myc activation in mouse epidermis led to the depletion of the epidermal stem cell compartment by altering adhesive interactions with the local microenvironment. This was evidenced by the transcriptional analysis of over 10,000 genes, revealing that Myc activation induced genes related to RNA and protein synthesis, cell proliferation, and differentiation, while downregulating over 40% of genes associated with cell adhesion and cytoskeleton proteins. These changes impaired keratinocyte adhesion, motility, and wound healing, correlating with decreased expression of extracellular matrix proteins and integrins, and reduced formation of hemidesmosomes and actomyosin cytoskeleton assembly. Consequently, Myc activation prompted stem cell exit and differentiation into sebocytes and interfollicular epidermis at the expense of hair lineages, due to impaired keratinocyte migration necessary for hair differentiation.
March 2024 in “Bioscientia medicina” The rs6152 allele is not a good marker for baldness in the Indonesian population, but family history, age, gender, high blood pressure, and body weight are linked to the risk.
March 2024 in “Egyptian Journal of Veterinary Science” Nandrolone decanoate damages the heart, liver, and kidneys.
April 2023 in “Journal of Investigative Dermatology” Two new IRAK4-inhibitors effectively reduced skin inflammation and immune response markers in healthy volunteers.
January 2021 in “Medical research archives” The 5% minoxidil lotion without propylene glycol is effective, well-tolerated, and cosmetically acceptable for hair loss.
2 citations,
January 2008 in “Journal of The American Academy of Dermatology” Trichoscopy is a helpful and quick method to diagnose hair loss without shaving.
91 citations,
December 2006 in “Proceedings of the National Academy of Sciences” Hair patterns in mice are controlled by both a global system dependent on Fz6 and a local self-organizing system.
44 citations,
February 2023 in “Cell” Fingerprints form uniquely before birth due to specific genetic pathways and local signals.
15 citations,
January 2015 in “Skin Appendage Disorders” Increased scalp sweating in frontal fibrosing alopecia may be linked to local skin inflammation.
10 citations,
October 2009 in “Photomedicine and laser surgery” IPL treatment can significantly reduce hair in faun tail but may need local anesthesia.
6 citations,
September 1998 in “Dermatologic surgery” Hair transplant surgeons did not agree on which drugs to use except for local anesthetics, and there was no strong evidence supporting their drug choices.
2 citations,
November 2022 in “Frontiers in Pharmacology” Local healers in Addis Ababa use 81 medicinal plants, mainly from the Asteraceae family, to treat skin and general diseases, with Echinops kebericho being an endangered plant important in their practices.
December 2023 in “Facial Plastic Surgery” Local anesthesia, often with sedation, effectively reduces pain in hair transplant harvesting.
October 2023 in “Facial Plastic Surgery” Local anesthesia with a "ring block" is preferred for pain control during FUE hair transplant procedures.
Local flaps are effective for covering small to large scalp and forehead defects with good cosmetic results.
Hair restoration surgery, done under local anesthesia, is used to hide scalp scars and treat certain alopecia stages, relying on transplant design and patient understanding for success.
October 2013 in “Clinics in Plastic Surgery” Local anesthesia is effective, safe, and cost-saving for plastic surgery.
November 2023 in “Turkish journal of botany” Türkiye uses many local plants to treat skin problems.
March 2022 in “International journal of biology, pharmacy and allied sciences” Ayurvedic treatment with local herbal applications successfully regrew hair in a patient with alopecia areata.
8 citations,
September 1958 in “Acta pathologica et microbiologica Scandinavica” Certain treatments can speed up local hair growth in mice but don't change the overall hair growth pattern.
February 2024 in “International Journal of Dermatology” The document concludes that more local research on African skin and hair is needed despite increased scientific output from Sub-Saharan Africa.
July 2020 in “International journal for research in applied science and engineering technology” The herbal shampoo made from local plants can reduce hair loss and promote hair growth.
Medicinal plants are important for local health in La Tranca Arriba.
521 citations,
January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
2 citations,
June 2018 in “Jurnal Penelitian dan Pengembangan Pertanian” Antioxidant-rich maize varieties can improve health and need local support for widespread farming.
1 citations,
January 2002 in “Journal of Clinical Dermatology” Hair loss in androgenic alopecia may be linked to increased local androgen activities, but not to estrogen levels.
Ginseng extract promoted hair growth in mice and improved local blood flow.
January 1953 in “The Lancet” Cortisone may help hair regrow by altering the local environment, with regrowth starting 3-4 weeks after treatment, but its use is not widely recommended.
75 citations,
September 2009 in “Dermato-endocrinology” The skin produces and processes hormones, affecting both local and overall body functions.
10 citations,
February 2015 in “Clinics in Dermatology” The document concludes that changes in eyelashes and eyelid skin can indicate various local and systemic diseases.