February 2008 in “Vlaams dierengeneeskundig tijdschrift” In this case report, a pancreatic adenocarcinoma with liver and omentum metastases was found in a cat, whose clinical signs included anorexia, diarrhea, lethargy, and non-pruritic glistening alopecia.
January 2026 in “European Journal of Dermatology” This article examines the use of legal amphetamines by French political figures from the Liberation to the 1960s, highlighting their impact on health and their prevalence among Communist activists, influenced by habits from the Resistance.
242 citations
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January 2000 This study identified a strong association between heavy metal contamination in drinking water and chronic diseases like renal failure and liver cirrhosis in Great Cairo Cities, Egypt.
103 citations
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February 1972 in “Proceedings of the National Academy of Sciences” This study found that a unique transglutaminase in guinea pig hair-follicles, distinct from liver transglutaminase, likely plays a role in forming protein cross-links via ε(γ-glutamyl)lysine bonds.
76 citations
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January 2017 in “World Journal of Stem Cells” This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.
65 citations
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October 2015 in “Acta Biomaterialia” This study found that using a pH-sensitive layered double hydroxide nanocarrier to deliver etoposide significantly reduced liver toxicity and enhanced the drug’s effectiveness in targeting and suppressing non-small cell lung cancer.
60 citations
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December 1988 in “Journal of Biochemical Toxicology” In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
46 citations
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September 2011 in “Journal of Endocrinology” This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
20 citations
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October 1995 in “PubMed” This study identified CYP3A4 as a key isozyme involved in the oxidative metabolism of finasteride in human liver microsomes.
17 citations
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August 2023 in “Frontiers in Pharmacology” This review highlights the potential of Asteraceae plants as antidiabetic agents and their beneficial effects on conditions such as cardiovascular disease and liver cirrhosis, suggesting their use as food and nutraceuticals could help manage diabetes.
13 citations
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January 2002 in “Clinics in dermatology” This study found that AHCC supplementation significantly reduced alopecia severity in Ara-C treated rats and mitigated liver injury-related side effects in mice treated with 6-MP and MTX.
10 citations
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March 2014 in “International Journal of Dermatology” This report describes a case of postoperative pressure-induced alopecia in a 5-year-old girl following liver transplantation, suggesting that scalp dermatoscopy may help differentiate this condition from alopecia areata.
9 citations
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January 1959 in “The journal of nutrition/The Journal of nutrition” This study found that a higher potassium diet in lysine-deficient rats partially protected against hair loss and increased liver fat, suggesting these rats require more potassium.
8 citations
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February 2014 in “General and Comparative Endocrinology” In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.
7 citations
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December 2023 in “International Journal of Molecular Sciences” This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.
5 citations
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May 2023 in “European Journal of Human Genetics” This study found that mutations in the TULP3 gene are associated with progressive degeneration of the liver, kidney, and heart in adults, highlighting the importance of early detection and management.
5 citations
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May 2006 in “Dermatologic Surgery” This study found that a PEEP of 10 mbar for 2 hours did not adversely affect liver function or gastric mucosal perfusion in patients after cardiac surgery, as long as cardiac output was maintained.
1 citations
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September 2023 This study reported that the combination of tridax procumbens and ginger juice improved antioxidant activity and protected against liver damage induced by paracetamol in rats, suggesting a potent hepatoprotective effect.
1 citations
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April 2022 in “Acta histochemica” This study found that oral pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, unlike finasteride and minoxidil which showed adverse effects.
1 citations
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December 2012 in “I P Pavlov Russian Medical Biological Herald” In this study, finasteride was found to induce tissue-specific P-glycoprotein activity in the liver and kidney of rabbits after a 14-day treatment period.
August 2026 in “Plant Science Today” This review synthesizes data on Eclipta alba, highlighting its traditional use for liver, skin, and general health, supported by preclinical evidence of hepatoprotective and other beneficial activities, while noting the need for more rigorous toxicological and clinical safety studies to substantiate its therapeutic applications.
June 2026 in “Nano Research” In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.
May 2026 in “Current Medicinal Chemistry” This systematic review suggests that human placental extracts may offer therapeutic benefits for non-communicable diseases such as liver pathologies and metabolic disorders, but larger trials are needed to confirm efficacy and understand molecular pathways.
February 2026 in “Diabetes Metabolic Syndrome and Obesity” This study identified a higher basal metabolic rate as an independent and causally relevant risk factor for nonalcoholic fatty liver disease in the Chinese population, noting that sex-specific effects may require tailored management strategies.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study tested the acute toxicity of Ficus platyphylla methanol leaf extract in Wistar rats and found no mortality or significant liver enzyme changes at doses up to 5000 mg/kg, suggesting a high margin of acute safety and supporting its traditional use under short-term exposure.
December 2025 in “Scientific Reports” In this study, cedrol was found to reduce lipid accumulation in the liver and adipose tissues of dexamethasone-treated mice by antagonizing glucocorticoid receptors, suggesting its potential utility in treating dexamethasone-induced lipid metabolism disorders.
October 2025 in “Benha Veterinary Medical Journal” In this study, the researchers reported that both dandelion and safflower extracts protected against liver and kidney damage caused by thioacetamide in rats, with safflower being more effective than both silymarin and dandelion.
January 2025 in “Indian Journal of Experimental Biology” In this study, mice orally exposed to carbon-based nanoparticles for 30 days showed significant liver and kidney changes, behavioral alterations, and physiological disturbances, suggesting potential severe health risks due to the nanoparticles' slow clearance and formation of reactive oxygen species.
In this study, homeopathic Radium bromatum showed potential anti-cancer effects against human lung and liver cancer cells in vitro while exhibiting low cytotoxicity towards non-cancerous kidney cells.
In this study, researchers identified an elite germplasm of the medicinal plant Eclipta alba, known for its liver disease benefits, with higher growth, yield, and wedelolactone content, suitable for large-scale cultivation to reduce strain on wild populations.