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This study provided the first X-ray crystal structure of the mammalian steroid hormone reductase AKR1D1 and identified a disease-related mutant, P133R, which may impact bile acid metabolism and cause clinical symptoms.

This study found that the ethyl acetate fraction of Hibiscus rosa sinensis petals significantly reduced serum glucose and glycated hemoglobin levels in diabetic rats, showing effects comparable to the standard drug metformin.

This study found that a hair follicle-like structure forms in nude mice when hair papilla cells are mixed with hair follicle epithelium and implanted, but not with dermal sheath cells or fibroblasts.

This case report describes a 40-year-old Indian male with sclerosing cholangitis whose skin lesions and liver function improved following surgical treatment.

This study provided a dynamic 4D atlas showing the development process of mouse hair follicles through a telescope-like model, revealing new insights into the origin of hair follicle stem cells.

This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.

This study found that excessive consumption of cloves in mice caused toxic changes in the liver, including structural damage and cell death, but concluded these effects are not considered dangerous.

Scientists used a special imaging technique to observe that hair follicle regeneration involves cell division and structural changes, mostly in the lower part of the follicle, and that the dermal papilla at the base is crucial for regrowth.

The conclusion is that the dermal papilla is crucial for hair follicle regrowth, and hair follicles undergo significant structural changes in addition to cell division during regeneration.

This study in rats with a portocaval shunt observed severe ultrastructural damage to the inner ear, associated with zinc deficiency and symptoms resembling liver cirrhosis in humans.

This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.

This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.

This study found that intermediate filaments and matrix proteins in presumptive hair shaft cells are synthesized sequentially, identifying a new polypeptide component that changes during hair cell differentiation.

This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.

This review highlights that isotretinoin effectively treats acne by addressing its pathogenic mechanisms, although managing its teratogenic risk and side effects through structured monitoring is crucial for safe use.

This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.

This review discusses the role of intermediate filaments in cell signaling and differentiation, emphasizing their impact on stem cell function, development, and disease, but reports no new clinical results.

This study explored how alopecia impacts the socio-emotional lives and daily adaptation of women, finding that while not life-threatening, alopecia initially affects how they adjust to daily routines and perceive social and partner relationships.

In this study, after long-term observation of human scalp hair follicles over 16 years, the researchers found that a topical 5% minoxidil solution could stimulate hair regrowth after a period of dormancy, though with reduced growth rates and hair diameter.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

This study investigated the effects of nandrolone decanoate on adult rabbits and reported that administering 10 mg/kg for 15 days caused harmful histological changes in the heart, liver, and kidneys, including inflammation and tissue degeneration.

This study found that hair follicle stem cells in mice have an unexpected ability to adaptively determine their differentiation pathways, maintaining tissue architecture despite external stimuli.

This study observed that in live rodents, actin filaments adjust their structure to facilitate membrane transfer between cellular compartments; linear filaments stabilize fused membranes, while branched filaments, connected by the protein Ezrin, drive integration, demonstrating actin's role in adapting to membrane biophysical changes.

This paper discusses insulin resistance's effects on skin physiology, emphasizes its role in keratinocyte balance, and reports no new experimental findings.

This study found that the expression of androgen receptors is higher in the scalp area affected by androgenetic alopecia, and its expression varies based on different traditional Chinese medicine syndromes.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This review summarizes recent advances in organoid technology for generating tissue models from the three germ layers and reports no new experimental results.

This study reports that human epidermal transglutaminase activity increases with treatment using organic solvents and chemicals without significant molecular weight changes, which may allow modulation of the enzyme in skin diseases.

In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.

This review discusses the dermatologic needs and care considerations for transgender patients undergoing gender transition, highlighting the unique role dermatologists can play, but it does not report new clinical results.