48 citations
,
February 2016 in “Scientific Reports” This study reports the creation of rat liver stem cell lines that can differentiate into hepatocytes and suggests they might be useful for pharmacological and regenerative medicine applications.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
74 citations
,
March 2013 in “Development” This study found that Hopx labels a long-lived progenitor population in hair follicles, which contributes to hair follicle stem cell homeostasis and has an alternative origin from previously thought progenitors.
15 citations
,
November 2020 in “Development” This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.
33 citations
,
March 2013 in “Journal of Investigative Dermatology” Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
9 citations
,
March 2019 in “European Journal of Sport Science” This article discusses laboratory and physical markers that may help detect androgenic anabolic steroid abuse in athletes and reports no new primary research results.
8 citations
,
January 2021 in “PubMed” This study suggests that hair follicle-derived mesenchymal stem cell transplantation may effectively treat acute pancreatitis by reducing inflammation and promoting pancreatic regeneration in a rat model.
26 citations
,
January 2019 in “Experimental Dermatology” This study developed an in vitro system to analyze human skin progenitor cells' ability to form hair peg-like structures, providing insights for engineering hair follicle organoids.
24 citations
,
May 2016 in “Stem Cell Reviews and Reports” This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.
October 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study demonstrates that using a K15 promoter-driven GFP labeling technique allows for the identification and characterization of epithelial stem cells in adult human hair follicles.
143 citations
,
September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
137 citations
,
April 2015 in “Nature Reviews Molecular Cell Biology” This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.
January 2008 in “Durham e-Theses (Durham University)” This study observed that stem cells from the hair follicle dermis share similarities with bone marrow-derived mesenchymal stem cells and have potential to form neural-like cells under specific conditions.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This research found that the microtubule catastrophe factor KIF18B plays a crucial role in promoting spindle orientation in keratinocytes, linking this process to cell fate decisions during hair follicle morphogenesis.
38 citations
,
January 2006 in “Journal of Cellular Biochemistry” This study reported the successful isolation of epithelial stem cells from mouse embryonic skin using a simple culture method, with the cells showing the potential to differentiate into multiple cell types.
6 citations
,
June 2012 in “Physiology” This review discusses current airway regeneration research efforts and reports no new experimental results, highlighting the need for clinical interventions to enhance airway repair.
9 citations
,
August 2015 in “Tissue Engineering and Regenerative Medicine” In this study, human dermal stem/progenitor cell-derived conditioned medium was found to promote hair regrowth in mice, possibly through effects on the Wnt/β-catenin pathway.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
April 2025 in “Cellular and Molecular Biology” This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.
291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
11 citations
,
October 2021 in “Stem Cell Research & Therapy” This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.
6 citations
,
May 2021 in “Stem Cell Reviews and Reports” This study identified and characterized progenitor cells from equine feet that may play a role in the pathogenesis and recovery of laminitis, suggesting potential therapeutic targets for treatment.
50 citations
,
September 2014 in “Stem cell reports” In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.
April 2018 in “Journal of Investigative Dermatology” This study found that hair follicle stem cells in mice have an unexpected ability to adaptively determine their differentiation pathways, maintaining tissue architecture despite external stimuli.
April 2018 in “Journal of Investigative Dermatology” This study found that Fgf20 signaling facilitates fibroblast migration and influences dermal condensate cell development during hair follicle morphogenesis by supporting cellular activities such as cell cycle exit and specific cell shape adoption.
November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study used a novel fluorescent tagging method in mice to observe collagen IV dynamics during hair follicle development, revealing that alterations in basement membrane turnover can influence epithelial progenitor cell behavior and organ morphology by affecting cell proliferation and movement.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reported that distinct stem/progenitor populations in the ocular surface epithelium have different cell division frequencies and respond differently to injury, with specific spatial compartmentalization and migration behaviors.
2 citations
,
November 2015 in “Actas Dermo-Sifiliográficas” This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.
This study reported a new method enabling the observation of the full leg regeneration process in the crustacean *Parhyale hawaiensis* over 10 days, capturing cellular resolution while minimizing photodamage, through innovative imaging techniques and computer-assisted cell tracking.
2 citations
,
December 2024 in “International Journal of Molecular Sciences” This study found that mesenchymal stem cells from chronically inflamed human livers maintain their key cellular characteristics, supporting their potential use in developing liver cell therapies.