research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors
Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
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research Actinic Keratosis: A Clinical and Epidemiological Review
Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.
research The Evolutionary Impact of Androgen Levels on Prostate Cancer in a Multi-Scale Mathematical Model
Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.
research Two Mechanisms Regulate Keratin K15 Expression in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signaling
Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
research Feline Non-Flea Induced Hypersensitivity Dermatitis
Cats can get skin issues from things other than fleas, like insect bites, food, or allergens.
research Elevated Ornithine Decarboxylase Activity Promotes Skin Tumorigenesis by Stimulating the Recruitment of Bulge Stem Cells but Not via Toxic Polyamine Catabolic Metabolites
Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration
New materials that better mimic natural skin structure could improve healing, especially for chronic wounds.
research Can Artificial Intelligence Hold a Dermoscope?—The Evaluation of an AI Chatbot to Translate the Dermoscopic Language
AI chatbots can help teach dermatology but need careful checking for accuracy.
research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers
Blocking YAP/TAZ could be a new way to treat skin cancer.
research Orchestration of Tissue-Scale Mechanics and Fate Decisions by Polarity Signaling
Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
research Epidermal Stem Cells in Orthopedic Regenerative Medicine
Epidermal stem cells show promise for treating orthopedic injuries and diseases.
research Editorial: Progress and Prospects on Skin Imaging Technology, Teledermatology, and Artificial Intelligence in Dermatology
New skin imaging, teledermatology, and AI could become key in future dermatology care.
research A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases
The new topical botanical formulation significantly regrew hair in all five patients without side effects.
research The Impact of Chemotherapy on the Nutritional Status of Breast Cancer Patients
Chemotherapy worsens nutritional status in breast cancer patients, requiring targeted nutritional strategies.
research Bachmann–Bupp Syndrome and Treatment
DFMO treatment improves hair growth, muscle tone, and development in Bachmann-Bupp syndrome patients.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation
TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
research Cronkhite-Canada Syndrome Associated with Colon Cancer Metastatic to Liver
A patient with Cronkhite-Canada Syndrome developed colon cancer that spread to the liver, showing the need for regular cancer checks in such patients.
research Integrin Beta 1 Establishes Liver Microstructure and Modulates Transforming Growth Factor Beta During Liver Development and Regeneration
Integrin β1 is crucial for liver structure and function, preventing fibrosis.
research Spironolactone and XPB: An Old Drug with a New Molecular Target
Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.
research Diagnosis and Treatment of Alopecia in an Older Dog with Abdominal Mass
The dog had a Sertoli cell tumor, which was successfully removed with surgery.
research The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia
A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.
research Sexual Dysfunction, Including Hypoactive Sexual Desire Disorder: Diagnosis and Treatment Recommendations
Testosterone therapy can improve sexual function in women but long-term safety is unclear.
research Androgen Treatment in Women
Testosterone therapy can help with androgen deficiency in women but should be used with caution and monitoring due to potential risks.
research MALDI Imaging Mass Spectrometry of Skin: Aspects of Sample Preparation
MALDI Imaging Mass Spectrometry is a useful method for studying skin conditions, but sample preparation is crucial for accurate results.
research The Developing Immune Network in Human Prenatal Skin
Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.
research Clinical Impact of Molecular Diagnostics in Endocrinology
Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.
research Non-Endocrine Alopecia in Dogs and Cats: Conditions, Treatments, and Prognoses
The document concludes that non-endocrine alopecia in pets varies in treatment effectiveness and often has a poor prognosis, especially in cats.
research Long-Term Satisfaction and Tolerability with Low-Dose Flutamide: A 20-Year Surveillance Study on 120 Hyperandrogenic Women
Low-dose flutamide improved hirsutism and satisfaction in women but had common side effects, causing some to stop treatment.