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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Finasteride helps brain function in rats with liver-related brain issues.

Finasteride helps treat hair loss by blocking enzyme activity.

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Choline and biotin are important for liver health and preventing certain deficiencies in animals, and more research is needed to understand their benefits in humans.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

About 41% of Indian hair loss patients have low enzyme activity that affects hair loss treatment effectiveness, with men affected more than women. Testing for this can guide treatment.

A certain medication improved severe itching in a boy with liver and bowel disease by reducing histamine levels, suggesting a new treatment target.

Finasteride may protect brain and improve behavior in rats with liver failure.

UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.

Cynoglossum amabile has medicinal potential but poses safety concerns due to liver toxicity.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.