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In this retrospective study, low-dose methotrexate was observed to be effective and well-tolerated in treating recalcitrant alopecia areata multiplex, achieving complete or near-complete hair regrowth in about 90% of patients despite some experiencing elevated liver enzymes and gastrointestinal discomfort.

This case report describes a rare instance where a young woman initially presented with macrophage activation syndrome as the first sign of systemic lupus erythematosus, and ultimately experienced multiorgan failure and death.

Blocking IL-1 could help treat some hair loss conditions; alopecia affects liver detox systems; spironolactone is better than finasteride for female hair growth; focusing on the catagen hair phase could lead to new alopecia treatments.

This literature review highlights the changing epidemiology of tinea capitis due to global migration and underscores the importance of early recognition and treatment of atypical variants in immunocompetent children to minimize prolonged systemic antifungal therapy and prevent adverse events, especially regarding liver health.

This study found that the dehydroepiandrosterone hydroxylating enzyme system in hair follicles is similar to the liver monooxygenase system, sharing characteristics such as inhibition by carbon monoxide and dependency on NADPH.

In this study, researchers characterized a dehydroepiandrosterone hydroxylating enzyme system in hair follicles similar to the liver monooxygenase system, noting its inhibition by carbon monoxide and its dependence on NADPH.

This review synthesizes information on isotretinoin’s systemic toxicity, emphasizing that its adverse effects, including mucocutaneous, hepatic, and musculoskeletal reactions, primarily reflect its pharmacodynamic actions and are generally manageable with individualized dosing and monitoring, though its teratogenicity remains a significant safety concern.

This research overview highlights that although JAK inhibitors show promise as potential treatments for alopecia areata based on recent insights into the disease mechanism, their efficacy has not yet been thoroughly evaluated in a systematic manner.

In this systematic review and meta-analysis, researchers found that methotrexate and leflunomide have similar efficacy for rheumatoid arthritis as first-line treatments, but methotrexate offered a greater reduction in swollen joints, while leflunomide was more associated with liver enzyme increases and fewer gastrointestinal side effects.

In this systematic review and meta-analysis, methotrexate and leflunomide were compared for treating rheumatoid arthritis, showing similar efficacy overall. Methotrexate reduced swollen joints more effectively, while leflunomide was associated with fewer gastrointestinal side effects but more frequent liver enzyme increases.

This study found that isotretinoin is a safe and well-tolerated acne treatment, with common adverse effects like cheilitis manageable through symptomatic medication and no significant changes in lipid or liver enzyme levels.

This case report describes an inflammatory skin reaction linked to kava kava ingestion, with the patient's condition resolving after treatment with oral prednisone and topical hydrocortisone.

This review discusses the etiology and clinical findings of atypical hyperadrenocorticism in dogs due to sex steroid imbalance and explores various treatment options, but reports no new results.

In this review, the authors report that topical minoxidil effectively stimulates hair growth in androgenic alopecia and to a lesser extent in nasal alopecia, particularly in early stages, with minimal and typically short-lived adverse skin reactions, but no systemic side effects.

This case report presented by the authors provides the first evidence of severe liver failure associated with the use of topical minoxidil, emphasizing the potential for hepatotoxicity even from drugs with minimal systemic absorption.

This study suggests that nanoliposomes encapsulating saw palmetto CO2 extract could be effective for delivering drugs to treat hair loss due to their small size, dispersion, and negative charge.

This study describes the efficacy of oral isotretinoin in treating severe, hormonal, and treatment-resistant acne, noting significant side effects that depend on dose and duration, including teratogenic risks and common issues like skin dryness, while underscoring the importance of systematic monitoring to mitigate adverse effects.

This study found that over 26% of patients using Tripterygium wilfordii Hook F experienced adverse events, highlighting the need for better strategies to manage these risks.

This study found that azathioprine may improve relapses and disability in patients with neuromyelitis optica spectrum disorder but is associated with higher adverse events compared to mycophenolate mofetil.

This review discusses the use of acitretin, a retinoid approved since 1997, for various forms of psoriasis and its potential benefits in combination therapy, but reports no new clinical findings.

This article reviews the presentations from the First Symposium of Ichthyosis Experts in Spain, held to address the challenges in organizing care for ichthyosis patients, and reports no new clinical results.

This case report describes a 69-year-old woman who developed drug-induced acquired ichthyosis related to ponatinib therapy, which improved upon stopping the medication.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This study reviewed recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, detailing its association with sexual dysfunction, mood disorders, insulin resistance, and other metabolic disorders, suggesting persistent biopsycho-social risks beyond transient side effects in users.

In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.

This review discusses various strategies, including vitamin A and dextromethorphan supplementation, to manage methotrexate toxicity and improve adherence in patients with rheumatic diseases, but reports no new clinical results.

This review discusses baricitinib's applications for various inflammatory disorders and highlights its promising efficacy alongside potential adverse effects, advocating for further research before it becomes a standard treatment.

This abstract describes a program with various presentations and events focused on Canadian excellence in rheumatology but reports no new research findings.

This review introduces pharmacophore technology and discusses its applications in toxicity prediction and limits, but reports no new clinical results.

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.