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The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The Rotterdam Study aims to understand various diseases in older adults.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.

Children with scalp fungal infections need proper diagnosis and treatment, usually with antifungal medications, and newer drugs may offer quicker recovery.

Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.

Both drugs lower DHT levels, with GI198745 being more effective.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Diane 35 plus finasteride is more effective in reducing hair growth and androgen levels, but may decrease libido.

Finasteride-loaded nanoparticles may help treat alopecia.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Ketoconazole cream is effective for skin conditions like seborrheic dermatitis and may help with hair loss and other skin issues, with generally mild side effects.

Certain hormone treatments can improve acne and related conditions in women.

Pregnancy can change skin disease severity, with some conditions improving and others worsening, and treatment should balance benefits and fetal safety.

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

Finasteride reduces hair growth and is safe for women with excessive hair.

Finasteride and flutamide both reduce hair growth, but finasteride has fewer side effects.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.