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In this study, oral tofacitinib was associated with significant hair regrowth in patients with alopecia areata, achieving over 50% reduction in Severity of Alopecia Tool scores, with mild side effects.

This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.

This study assessed the impact of hormonal contraceptives on liver function in 46 women aged 25-45 and found that contraceptive users, particularly those using combined oral contraceptives, had significantly higher liver enzyme levels compared to non-users, suggesting potential adverse effects that warrant further investigation.

This study on diabetic rats reported that Ziziphus spina-christi ethanol leaf extract significantly reduced blood glucose levels and improved liver and kidney function, suggesting possible benefits in managing diabetes symptoms in this animal model.

In this study of Bulgarian women, the waist-to-stature ratio was a better marker for an unfavorable metabolic profile than the waist-to-hip ratio among those with PCOS and obesity.

This study observed that testosterone therapy in transgender men enhances both physical and mental health, is safe in the short and middle term with proper follow-up, and highlights the need for endocrinologists to provide gender-affirming care despite its limited presence in medical education.

In this study, female-to-male transsexuals treated with long-acting testosterone undecanoate experienced an increase in lean mass but no change in fat mass or bone mineral density over 24 months.

In this study, a very low-calorie ketogenic diet significantly improved metabolic and hormonal profiles in obese men, but did not significantly enhance most semen parameters except for sperm motility.

This study found that anthocyanins from Hibiscus rosa-sinensis petals reduced oxidative stress and increased antioxidant enzyme activity in the livers of streptozotocin-induced diabetic rats.

The researchers reported that epitestosterone treatment reduced eicosanoid levels generated by cyclooxygenases and lipoxygenases in rabbit liver samples with carrageenan-induced inflammation.

This study found that over 26% of patients using Tripterygium wilfordii Hook F experienced adverse events, highlighting the need for better strategies to manage these risks.

This study describes the efficacy of oral isotretinoin in treating severe, hormonal, and treatment-resistant acne, noting significant side effects that depend on dose and duration, including teratogenic risks and common issues like skin dryness, while underscoring the importance of systematic monitoring to mitigate adverse effects.

This study tested the acute toxicity of Ficus platyphylla methanol leaf extract in Wistar rats and found no mortality or significant liver enzyme changes at doses up to 5000 mg/kg, suggesting a high margin of acute safety and supporting its traditional use under short-term exposure.

This study reviews classical Ayurvedic texts and modern research on Amalaki, finding significant benefits for lipid profiles, blood glucose, and inflammation in clinical trials, while also suggesting potential benefits for liver, hair, skin, eyes, cognition, and respiratory health based on preclinical data and traditional claims.

This study found that the methanol leaf extract of Ficus platyphylla demonstrated a high margin of acute safety in Wistar rats, showing minimal risk under short-term exposure with no mortality at doses up to 5000 mg/kg and no significant changes in liver enzyme activities.

In this systematic review and meta-analysis, researchers found that methotrexate and leflunomide have similar efficacy for rheumatoid arthritis as first-line treatments, but methotrexate offered a greater reduction in swollen joints, while leflunomide was more associated with liver enzyme increases and fewer gastrointestinal side effects.

In this systematic review and meta-analysis, methotrexate and leflunomide were compared for treating rheumatoid arthritis, showing similar efficacy overall. Methotrexate reduced swollen joints more effectively, while leflunomide was associated with fewer gastrointestinal side effects but more frequent liver enzyme increases.

This review discusses the pharmacological profile of teriflunomide for treating relapsing multiple sclerosis, highlighting its safety and effectiveness in reducing relapses and slowing disability progression, though direct comparisons with other oral medications are lacking.

This study found that rats fed diets with heated corn or peanut oil showed signs of toxicity, including liver and kidney weight increases, diarrhea, and ceased spermatogenesis, compared to those consuming fresh oils.

This study observed that successful weight loss following bariatric surgery may improve some skin conditions and metabolic profiles, but also may lead to a decrease in vitamin B12 levels, suggesting a need for nutritional supplements.

This study observed that dalpiciclib is associated with fewer adverse events like diarrhea and hepatotoxicity compared to other CDK4/6 inhibitors, potentially offering better patient-perceived safety and quality of life.

This review outlines the main findings from clinical trials on teriflunomide's efficacy and safety for relapsing multiple sclerosis, noting clinical considerations and exploring its mechanisms based on various studies.

This review discusses the use of acitretin, a retinoid approved since 1997, for various forms of psoriasis and its potential benefits in combination therapy, but reports no new clinical findings.

This review discusses teriflunomide as a disease-modifying therapy for multiple sclerosis and highlights its effectiveness and safety in clinical trials, but reports no new clinical results.

This review discusses baricitinib's applications for various inflammatory disorders and highlights its promising efficacy alongside potential adverse effects, advocating for further research before it becomes a standard treatment.

This review summarizes updated US prescribing information for teriflunomide in relapsing multiple sclerosis, highlighting its efficacy in reducing lesion activity and relapse rates but noting potential adverse effects such as headache and diarrhea.

This review of teriflunomide for relapsing-remitting multiple sclerosis examines its clinical and safety outcomes, finding it significantly reduces relapse rates and disability progression while being generally well-tolerated.

In this study, researchers assessed the effects of deferasirox in 85 children with ß-thalassemia in Kirkuk and reported that while 55.3% experienced a reduction in serum ferritin, 9.4% had adverse effects, indicating that deferasirox is generally well-tolerated as an iron chelator with modifiable side effects.

This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.

In this case report, a 45-year-old man with treatment-resistant androgenetic alopecia experienced hair regrowth during oral bicalutamide treatment but also suffered adverse effects leading to discontinuation, highlighting the need for further studies on the safety and role of androgen receptor blockade in hair loss.