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Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.

A man with multiple autoimmune diseases developed liver injury from azathioprine, but his liver improved after stopping the drug.

Biotin supplementation during isotretinoin treatment for acne may help maintain skin hydration and improve hair growth.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Autophagy is crucial for normal sebaceous gland function and sebum composition.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Biotin helps regulate proteins in the blood, which may explain its role in hair growth.

The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Certain Dibenzo derivatives may help treat prostate cancer.

Decomposed tritiated thymidine is less accurate for DNA tracing, and hair changes can indicate malnutrition.

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Stress, nutritional issues, and chronic diseases can cause hair loss, and nail changes may signal internal diseases; treatment focuses on the underlying cause.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Hair regrowth slows with age and can be affected by treatments that change enzyme activity in the skin.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.

Most pregnant women experience skin changes, mainly increased pigmentation, and some develop pregnancy-related skin conditions and infections.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.

Combining lifestyle changes and medication is most effective for managing PCOS symptoms.

The weight loss drug Orlistat can cause liver damage and should be used with caution, especially in those with liver or kidney issues.

A mother's diet at conception can cause lasting genetic changes in her child.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.